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The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie ...
Mixts. prepd. from alkyltriphenylphosphonium bromides and powd. NaNH2 were stored indefinitely. Upon addn. of an ethereal solid, however, they immediately generated the ylide, which then reacted with aldehydes, ketones, and formates. The use of such instan ...
cf. CA 55, 23400c. The Cu salt decompn. of diazo compds. in the presence of Ph3P opens up a new path to the synthesis of phosphorus-ylides. Ph3P (10 millimoles) and 10 millimoles 0.6M CH2N2 in Et2O treated 15 min. with 1 millimole anhyd. CuCl in 70 ml. tet ...
cf. CA 55, 13345i. MeOCH2Ph3PCl (I), m. 201-2 Deg (decompn.) (CHCl3-AcOH), was prepd. (86%) from 0.19 mole Ph3P (II) and 0.2 mole ClCH2OMe in 120 ml. C6H6 (60 hrs. at 50 Deg); I borate analog m. 198-9 Deg (Me2CO-EtOH). Ph2CO (0.02 mole) dissolved in 40 ml. ...
Drugs that allosterically modulate G protein-coupled receptor (GPCR) activity display higher specificity and may improve disease treatment. However, the rational design of compounds that target the allosteric site is difficult, as conformations required fo ...
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (r ...
Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mi ...
The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie ...
