Concept

Proline

Related publications (40)

Enhancing the proline effect: Pseudo-prolines for tailoring cis/trans isomerization

Cis-trans isomerization of proline-like oxazolidines and thiazolidines, denoted pseudo-prolines, is investigated spectrophotometrically with a chymotrypsin coupled assay and by H-1 NMR. A series of peptides carrying substituents of varying stereochemistry ...

1998

Pseudo-prolines as a molecular hinge: Reversible induction of cis amide bonds into peptide backbones

Serine, threonine-derived (4S)-oxazolidine-4-carboxylic acid, and cysteine-derived (4R)-thiazolidinecarboxylic acid, denoted pseudo-proline (Xaa[Psi(R1,R2)pro]), serve as structure disrupting, solubilizing building blocks in peptide synthesis. Variation of ...

1997

Molecular structure of the lipoamide dehydrogenase domain of a surface antigen from Neisseria meningitidis

The protein p64k from the surface of the Neisseria meningitidis bacteria has been characterized as a two-domain protein. It contains a dihydrolipoamide dehydrogenase domain of 482 residues, involving a FAD prosthetic group as a cofactor, and a smaller lipo ...

1997

Solution structure of regioselectively addressable functionalized templates: An NMR and restrained molecular dynamics investigation

Three cyclic peptides that are Regioselectively Addressable Functionalized Templates (RAFT) for use in protein de novo design have been investigated using a combination of nmr, restrained molecular dynamics, and CD spectroscopy. These peptides contain up t ...

1996

Structural fluctuations between two conformational states of a transmembrane helical peptide are related to its channel-forming properties in planar lipid membranes

Horst Vogel

Putative transmembrane helixes of membrane proteins in general and channel proteins in particular often contain proline residues which may induce a bend into an otherwise regular helical structure. Here, it is shown by fluorescence-energy-transfer measurem ...

1993

Accurate determination of scalar couplings by convolution of complementary two-dimensional multiplets

Geoffrey Bodenhausen

The authors describe how the value of a nuclear spin coupling const. JAX can be detd. very accurately by comparing 2 complementary 2-dimensional multiplets obtained with selective correlation NMR spectroscopy (soft-COSY) and with pure in-phase correlation ...

1993

Structure and dynamics of polypeptides and proteins in lipid membranes

Horst Vogel

A review, with .apprx.75 refs., on (1) structural models of membrane proteins derived from Raman spectroscopy and prediction methods, (2) dynamics of model peptides, (3) proline in transmembrane helixes, and other topics. [on SciFinder (R)] ...

1992

Involvement of residues 296-299 in the enzymatic activity of tissue-type plasminogen activator

Florian Maria Wurm

The tetra-alanine substitution variant KHRR 296-299 AAAA of tissue-type plasminogen activator (t-PA) was previously shown to have enhanced fibrin specificity and enhanced activity in the presence of fibrin compared with the wild-type form of the molecule. ...

1992

Enhanced cis-selectivities in olefination reactions employing ylides with modified stationary groups

Whereas triphenylphosphonioethanide manifests unsatisfactory cis-selectivities (84.0-95.5%), tris(o,o'-difluorophenyl)- and tri-o-tolylphosphonioethanide react with aliph. or arom. aldehydes and, resp., 2-alkenals or 2-alkynals to afford the olefins with c ...

1986

Peptide conformations. 28. Relayed heteronuclear correlation spectroscopy and conformational analysis of cyclic hexapeptides containing the active sequence of somatostatin

Geoffrey Bodenhausen

Homo- and heteronuclear 2-dimensional NMR techniques were used to assign the 1H and 13C NMR spectra of title cyclic peptides cyclo[Phe7-D-Trp-Lys(COCH2Ph)-Thr-X11-Pro6] [X = Gly (I), Phe (II)] in Me2SO. Unequivocal assignments of C resonances of Trp and Ph ...

1983

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