Concept

Hereditary cancer syndrome

Related publications (204)

MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes

Recent advances in cancer biology have emerged important roles for microRNAs (miRNAs) in regulating tumor responses. However, their function in mediating intercellular communication within the tumor microenvironment is thus far poorly explored. Here, we fo ...

Nature Publishing Group2015

Memristive Biosensors for PSA-IgM Detection

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki

Prostate cancer is the most common cancer among men except for skin cancer, and the detection at early stages is crucial. In the present work, nanofabricated memristive biosensors are subjected to surface bio-modification targeting at prostate-specific ant ...

2015

Lead Optimisation of a Novel Small Molecule Notch Inhibitor

Viktoria Reinmüller

Notch signalling represents a form of cell-to-cell communication that plays a pivotal role for cellular organisation during embryonic and postnatal development, as well as in the homeostasis of adult organs and tissues. Malfunction of this signalling pathw ...

EPFL2015

Metabolic expressivity of human genetic variants: NMR metabotyping of MEN1 pathogenic mutants

David Lyndon Emsley

Functional consequences of mutations in predisposition genes for familial cancer syndromes remain often elusive, especially when the corresponding gene products play pleiotropic functions and interact with numerous partners. Understanding the consequences ...

ELSEVIER SCIENCE BV2014

Functionalization of Nanoparticles for Targeted Cancer Imaging and Diagnosis

Solène Marcelle Françoise Marie Passemard

At present time, cancer is the leading cause of death in developed countries. The medical imaging tools currently used in clinics such as radiology, nuclear magnetic resonance imaging, microscopy and endoscopy are not able to reach the sensitivity necessar ...

EPFL2014

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells

Nadine Fournier, Mauro Delorenzi, Simone Ragusa, Stavros Milatos

The Wnt pathway is abnormally activated in the majority of colorectal cancers, and significant knowledge has been gained in understanding its role in tumor initiation. However, the mechanisms of metastatic outgrowth in colorectal cancer remain a major chal ...

Elsevier2014

SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer

Paloma Ordonez Moran, Anja Irmisch

SPROUTY2 (SPRY2) is an intracellular regulator of receptor tyrosine kinase signaling involved in cell growth, differentiation and tumorigenesis. Here, we show that SPRY2 is a target gene of the Wnt/beta-catenin pathway that is abnormally activated in more ...

Nature Publishing Group2014

Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Livan Bladimir Alonso Sarduy

Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. I ...

American Chemical Society2013

Inhibitors of notch signalling pathway and use thereof in treatment of cancers

Jieping Zhu, Freddy Radtke, Rajwinder Lehal

The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers. ...

2013

Solute carriers (SLCs) in cancer

Pascale Anderle Pedone

During tumor progression cells acquire an altered metabolism, either as a cause or as a consequence of an increased need of energy and nutrients. All four major classes of macromolecules are affected: carbohydrates, proteins, lipids and nucleic acids. As a ...

Elsevier2013

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