Concept

Hereditary cancer syndrome

Related publications (204)

Studying cancer cells phenotypes integrating omics data in human reduced genome-scale metabolic models.

Vassily Hatzimanikatis, Maria Masid Barcon, Vikash Kumar Pandey

Cancer is a leading cause of death in the world, and the mechanisms underlying this disease are still not completely understood. In the last decades, altered tumour metabolism has been recognized as a hallmark of cancer. This has created a resurgence of in ...

2018

microRNA biosensors: Opportunities and challenges among conventional and commercially available techniques

Sandro Carrara, Tugba Kilic

As being the most extensively studied, non-coding, evolutionary conserved, post-transcriptional gene regulators of genome, microRNAs (miRNAs) have taken great attention among various disciplines due to their important roles in biological processes and link ...

2018

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

Etienne Meylan, Caroline Anne-Lyse Contat, Pierre-Benoit Bernard Ancey

Solute carriers of the glucose transporter (GLUT) family mediate the first step for cellular glucose usage. The upregulation of GLUTs has been reported in numerous cancer types as a result of perturbation of gene expression or protein relocalization or sta ...

WILEY2018

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Candice Megan T Young

Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitul ...

2018

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

Douglas Hanahan, Mohammad Sadegh Saghafinia, Giovanni Ciriello, Marco Mina

The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify a ...

CELL PRESS2018

The mechanism of tumour cell death by metal-based anticancer drugs is not only a matter of DNA interactions

Paul Joseph Dyson, Gianni Sava

Platinum drugs are extensively used in the clinic to treat cancer, often leading to a palliative response rather than a cure. While DNA is considered to be the primary target of platinum drugs, there is no clear relationship between cellular platinum accum ...

2018

Telomeric states in cancer development

Jana Majerská

Telomere dysfunction can unleash genome instability or permanently arrest cell proliferation, and thereby contribute to the processes of cancer and aging. Proper telomere function relies on many proteins that form part of its structure. Some telomeric prot ...

EPFL2018

Novel compartment-specific biosensors reveal a complementary subcellular distribution of bioactive Furin and PC7

Pierpaolo Ginefra

Proprotein Convertases (PCs) constitute a family of serine proteases that activate various hormones, growth factors and cell adhesion molecules by mediating endoproteolytic cleavage of their secreted inactive precursors during their transit in the secret ...

EPFL2018

Cytosolic delivery and characterization of monobodies interfering with SH2 domain-phosphotyrosine interactions

Nadine Eliane Schmit

Targeted cancer therapy is a very promising concept; however, small molecule inhibitors only exist for a limited number of oncoproteins and resistance development limits their clinical use. Different engineered non-antibody scaffolds are being explored to ...

EPFL2018

Inequality in genetic cancer risk suggests bad genes rather than bad luck

Mats Julius Stensrud

Heritability is often estimated by decomposing the variance of a trait into genetic and other factors. Interpreting such variance decompositions, however, is not straightforward. In particular, there is an ongoing debate on the importance of genetic factor ...

2017

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