Publications related to Heart development

Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Andrew Charles Oates, Mahmut Selman Sakar, Ece Özelçi, Erik Mailand, Matthias Rüegg

Classic microsurgical techniques, such as those used in the early 1900s by Mangold and Spemann, have been instrumental in advancing our understanding of embryonic development. However, these techniques are highly specialized, leading to issues of inter-ope ...

2022

Capturing Cardiogenesis in Gastruloids

Matthias Lütolf, Romain Guiet, Giuliana Rossi, Andrea Boni, Nicolas Antoine Vincent Broguiere, Mehmet Ugur Girgin

Organoids are powerful models for studying tissue development, physiology, and disease. However, current culture systems disrupt the inductive tissue-tissue interactions needed for the complex morphogenetic processes of native organogenesis. Here, we show ...

CELL PRESS2021

Tissue Engineering with Mechanically Induced Solid‐Fluid Transitions

Mahmut Selman Sakar, Ece Özelçi, Jaemin Kim, Erik Mailand, Nikolaos Bouklas, Matthias Rüegg, Jon Märki, Odysseas Konstantinos Chaliotis

Epithelia are contiguous sheets of cells that stabilize the shape of internal organs and support their structure by covering their surfaces. They acquire diverse morphological forms appropriate for their specific functions during embryonic development, suc ...

2021

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

Cédric Gobet, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Meltem Weger

The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development. We showed that knockdown of mond ...

2020

The emergence and promise of single-cell temporal-omics approaches

Gioele La Manno, Alex Russell Lederer

Single-cell transcriptomics enables the measurement of gene expression in complex biological systems at the resolution of individual cells. Multivariate analysis of single-cell data helps describe the variation in expression accompanying cellular processes ...

CURRENT BIOLOGY LTD2020

Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1(+) epicardial cells

Na Li

Brain natriuretic peptide (BNP) treatment increases heart function and decreases heart dilation after myocardial infarction (MI). Here, we investigated whether part of the cardioprotective effect of BNP in infarcted hearts related to improved neovascularis ...

ELIFE SCIENCES PUBLICATIONS LTD2020

Feasibility of neurochemically profiling mouse embryonic brain and its development in utero using 1 H MRS at 14.1 T

Hongxia Lei, Sébastien Robert Victor Herzig

We aimed to evaluate the feasibility of neurochemical profiling of embryonic mouse brain developments in utero and to seek potential in vivo evidence of an energy shift in a mitochondrial pyruvate carrier 1 (MPC1) deficient mouse model. C57BL/6 embryonic m ...

2019

Embryonic lateral inhibition as optical modes: An analytical framework for mesoscopic pattern formation

Andrew Charles Oates, Jose Negrete Jr

Cellular checkerboard patterns are observed at many stages of embryonic development. We study an analytically tractable model for lateral inhibition and show that the steady states are analogous to optical phonons at the Gamma point, which have the wave nu ...

2019

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Heart development

Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Morphomechanical Model Of The Torsional C-Looping In The Embryonic Heart

Capturing Cardiogenesis in Gastruloids

Tissue Engineering with Mechanically Induced Solid‐Fluid Transitions

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

The emergence and promise of single-cell temporal-omics approaches

Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1(+) epicardial cells

Feasibility of neurochemically profiling mouse embryonic brain and its development in utero using 1 H MRS at 14.1 T

Embryonic lateral inhibition as optical modes: An analytical framework for mesoscopic pattern formation

Robust Baseline Measurement for Reliable Fetal Heart Rate Evaluation

Graph Chatbot

Chat with Graph Search

Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Morphomechanical Model Of The Torsional C-Looping In The Embryonic Heart

Feasibility of neurochemically profiling mouse embryonic brain and its development in utero using 1 H MRS at 14.1 T

Tissue Engineering with Mechanically Induced Solid‐Fluid Transitions

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

Embryonic lateral inhibition as optical modes: An analytical framework for mesoscopic pattern formation

Robust Baseline Measurement for Reliable Fetal Heart Rate Evaluation