Concept
Cyclic compound
Related publications (248)
Methods for high-throughput synthesis and screening of peptide libraries
Macrocycles provide an attractive modality for drug development but the identification of ligands to targets of interest is hindered by the lack of large macrocyclic compound libraries for high-throughput screening. A strategy to efficiently synthesize lar ...
EPFL2024Synthesis and Applications of Ynimines and Enantioselective Total Synthesis of Artatrovirenol A
The first chapter of this thesis describe the development of a general synthesis of ynimines, an under-exploited motif in organic chemistry. In the presence of an inexpensive copper catalyst and 2,2'-biquinoline, reaction of easily accessible O-acyloximes ...
EPFL2023Oxidative rearrangement of 1,1-disubstituted alkenes to ketones
Qian Wang, Jieping Zhu, Qiang Feng
The Wacker process, which is widely used to convert monosubstituted alkenes into the corresponding methyl ketones, is thought to proceed through a PdII/Pd0 catalytic cycle involving a b-hydride elimination step. This mechanistic scenario is inapplicable to ...
2023