Publications related to Cyclic compound

Extrapolating the Fragment-Based Approach to Inorganic Drug Discovery

Paul Joseph Dyson, Lucinda Kate Batchelor

The fragment-based approach is a well-established strategy for organic drug discovery. Recent studies have shown that this approach also has considerable potential in medicinal inorganic chemistry, and yet the approach has not been formally described. Here ...

ELSEVIER2019

Incarceration of Iodine in a Pyrene-Based Metal-Organic Framework

Kyriakos Stylianou, Ngoc Tú Nguyên, Andrzej Gladysiak, Mariana Spodaryk

A pyrene-based metal-organic framework (MOF) SION-8 captured iodine (I-2) vapor with a capacity of 460 and 250 mg g(MOF)(-1) at room temperature and 75 degrees C, respectively. Single-crystal X-ray diffraction analysis and van-der-Waals-corrected density f ...

2019

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

Gerardo Turcatti, Julien Bortoli Chapalay, Xudong Kong, Van Manh Pham, Patrick Andreas Gonschorek, Sangram Shivdas Kale, Milan Bergeron-Brlek, João Miguel Franco Machado

Macrocyclic compounds are an attractive modality for drug development, but the limited availability of large, structurally diverse macrocyclic libraries hampers the discovery of leads. Here, we describe the discovery of efficient macrocyclization reactions ...

2019

Lewis acid catalyst-steered divergent synthesis of functionalized vicinal amino alcohols and pyrroles from tertiary enamides

Jieping Zhu, Shuo Tong

We report herein two Lewis acid catalyst-steered distinct reaction pathways of N-formylmethyl tertiary enamides. In the presence of a catalytic amount of AlCl3 and 4 angstrom molecular sieves, the stable N-formylmethyl tertiary enamides underwent sequentia ...

ROYAL SOC CHEMISTRY2018

Applying a Trojan Horse Strategy to Ruthenium Complexes in the Pursuit of Novel Antibacterial Agents

Paul Joseph Dyson, Lucinda Kate Batchelor, Quentin François Antoine Laurent

Siderophores are iron chelators secreted by bacteria to scavenge iron(III) from their surrounding environment. They possess their own internalization pathway that is sufficiently unselective to be hijacked, making them suitable for Trojan Horse strategy ap ...

2018

Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids

Qian Wang, Jieping Zhu, Zhengren Xu

From tryptamine and secologanine, nature generates monoterpene indole alkaloids with an unprecedented level of skeletal diversity through a ‘couple–divert’ sequence. Intrigued by this biosynthetic machinery, new strategies and tactics to access skeletally ...

2018

Divergent Asymmetric Synthesis of Polycyclic Compounds via Vinyl Triazenes

Rosario Scopelliti, Kay Severin, Nicolai Cramer, Gregor Kiefer, Abdusalom Suleymanov, Florian Gérald Abela, David Kossler

Vinyl triazenes were obtained by enantioselective [2+2] cycloaddition reactions of bicyclic alkenes with 1-alkynyl triazenes in the presence of a RuII catalyst with a chiral cyclopentadienyl ligand. These triazenes serve as unique vinyl cation surrogates. ...

2017

Indole- and Pyrrole-BX: Bench-Stable Hypervalent Iodine Reagents for Heterocycle Umpolung

Jérôme Waser, Stefano Nicolai, Paola Caramenti

The one-step synthesis of the bench-stable hypervalent iodine reagents IndoleBX and PyrroleBX using mild Lewis acid catalyzed conditions is reported. The new reagents are stable up to 150 degrees C and were applied in the C-H arylation of unactivated arene ...

2017

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Cyclic compound

Extrapolating the Fragment-Based Approach to Inorganic Drug Discovery

Incarceration of Iodine in a Pyrene-Based Metal-Organic Framework

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

Developing Reactions of Strained Rings

Lewis acid catalyst-steered divergent synthesis of functionalized vicinal amino alcohols and pyrroles from tertiary enamides

Applying a Trojan Horse Strategy to Ruthenium Complexes in the Pursuit of Novel Antibacterial Agents

Dyes, Radicals and Nitrous Oxide Adducts Derived from N-Heterocyclic Carbenes

Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids

Divergent Asymmetric Synthesis of Polycyclic Compounds via Vinyl Triazenes

Indole- and Pyrrole-BX: Bench-Stable Hypervalent Iodine Reagents for Heterocycle Umpolung

Graph Chatbot

Chat with Graph Search

Extrapolating the Fragment-Based Approach to Inorganic Drug Discovery

Dyes, Radicals and Nitrous Oxide Adducts Derived from N-Heterocyclic Carbenes

Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids

Incarceration of Iodine in a Pyrene-Based Metal-Organic Framework

Lewis acid catalyst-steered divergent synthesis of functionalized vicinal amino alcohols and pyrroles from tertiary enamides

Applying a Trojan Horse Strategy to Ruthenium Complexes in the Pursuit of Novel Antibacterial Agents

Developing Reactions of Strained Rings

Indole- and Pyrrole-BX: Bench-Stable Hypervalent Iodine Reagents for Heterocycle Umpolung

Divergent Asymmetric Synthesis of Polycyclic Compounds via Vinyl Triazenes

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands