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Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPAR gamma 2-specific exon B, resulting in a white adipose tissue knockdown of PPAR ...
Background Physical and functional losses due to aging and diseases decrease human mobility, independence, and quality of life. This study is aimed at summarizing and quantifying these losses in order to motivate solutions to overcome them with a special f ...
There is strong evidence to suggest that inducible displacements, migration and implant loosening are closely related to the initial mechanical environment of the implanted tibia. If this is true, then it should be possible to predict the likelihood of imp ...
We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to reduced energy expen ...
We investigated the integration of neck muscle afferents during walking and running. Subjects walked or ran straight ahead, with or without an additional mass (20% of body weight). They performed all trials without vibration and with continuous vibration ( ...
We aim at developing autonomous micro-flyers capable of navigating within houses or small built environments. The severe weight and energy constraints of indoor flying platforms led us to take inspiration from flying insects for the selection of sensors, s ...
Our goal is to demonstrate the ability of bio-inspired techniques to solve the problem of piloting an autonomous 40-grams aircraft within textured indoor environments. Because of severe weight and energy constraints, inspiration has been taken from the fly ...
In a systematic search for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) target genes, we identified S3-12 and perilipin as novel direct PPAR-gamma target genes. Together with adipophilin and tail-interacting protein of 47 kDa, these genes ...
In this study, we defined the role of peroxisome proliferator-activated receptor beta/delta (PPARdelta) in metabolic homeostasis by using subtype selective agonists. Analysis of rat L6 myotubes treated with the PPARdelta subtype-selective agonist, GW501516 ...
A fundamental statistical problem is to indicate which of two hypotheses is better supported by the data. Statistics designed for this purpose are called weight of evidence. In this paper we study the problem of robust weights of evidence, optimal in their ...
