Concept
Essential gene
Related publications (38)
Characterization of the electron-accepting part of the organohalide respiration chain of Dehalobacter and Desulfitobacterium
Organohalide respiration (OHR) is a bacterial anaerobic process that use halogenated compounds, e.g. tetrachloroethene (PCE), as terminal electron acceptors. D. restrictus strain PER-K23, an obligate OHR bacterium (OHRB), and D. hafniense strain TCE1, a ba ...
EPFL2022Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA
The rnlAB toxin-antitoxin operon from Escherichia co/ifunctions as an anti-phage defense system. RnlA was identified as a member of the HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding domain) superfamily of ribonucleases. The activity of the tox ...
OXFORD UNIV PRESS2021A partially self-regenerating synthetic cell
Sebastian Maerkl, Barbora Lavickova, Nadanai Laohakunakorn
Self-regeneration is a fundamental function of all living systems. Here we demonstrate partial molecular self-regeneration in a synthetic cell. By implementing a minimal transcription-translation system within microfluidic reactors, the system is able to r ...
NATURE RESEARCH2020Disruption of the SucT acyltransferase in Mycobacterium smegmatis abrogates succinylation of cell envelope polysaccharides
Similar to other prokaryotes, mycobacteria decorate their major cell envelope glycans with minor covalent substituents whose biological significance remains largely unknown. We report on the discovery of a mycobacterial enzyme, named here SucT, that adds s ...
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2019