Concept
Botulinum toxin
Related publications (35)
The role of the inflammasome in cellular responses to toxins and bacterial effectors
Françoise Gisou van der Goot Grunberg
Invading pathogens are recognized by mammalian cells through dedicated receptors found either at the cell surface or in the cytoplasm. These receptors, like the trans-membrane Toll-like Receptors (TLR) or the cytosolic Nod-like Receptors (NLR), initiate in ...
Springer-Verlag2007Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Laure Gurcel
Many pathogenic organisms produce pore-forming toxins as virulence factors. Target cells however mount a response to such membrane damage. Here we show that toxin-induced membrane permeabilization leads to a decrease in cytoplasmic potassium, which promote ...
2006Anthrax toxin: the long and winding road that leads to the kill
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
The past five years have led to a tremendous increase in our molecular understanding of the mode of action of the anthrax toxin, one of the two main virulence factors produced by Bacillus anthracis. The structures of each of the three components of the tox ...
Elsevier2005Structural basis and biophysical properties of synaptic plasticity studied by atomic force microscopy
In this thesis, we studied two systems important for synaptic plasticity, one presynaptic and another postsynaptic. The protein complex composed of VAMP 2, SNAP-25 and syntaxin 1 (SNARE complex) is essential for docking and fusion of neurotransmitter-fille ...
EPFL2004Aerolysin from Aeromonas hydrophila and related toxins
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
Aeromonads are ubiquitous gram-negative bacteria found in aqueous environments. Some members of the genus are pathogenic for fish, reptiles and cows. In humans, Aeromonas infection is mainly associated with grastrointestinal diseases, but in immuno-comprom ...
2001Not as simple as just punching a hole
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
Like a variety of other pathogenic bacteria, Aeromonas hydrophila secretes a pore-forming toxin that contribute to its virulence. The last decade has not only increased our knowledge about the structure of this toxin, called aerolysin, but has also shed li ...
2001Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene
Clostridium perfringens phospholipase C (PLC), also called alpha-toxin, is the major virulence factor in the pathogenesis of gas gangrene. The toxic activities of genetically engineered alpha-toxin variants harboring single amino-acid substitutions in thre ...
2000Dimer dissociation of the pore-forming toxin aerolysin precedes receptor binding
Françoise Gisou van der Goot Grunberg
The pore-forming toxin aerolysin is secreted by Aeromonas hydrophila as an inactive precursor. Based on chemical cross-linking and gel filtration, we show here that proaerolysin exists as a monomer at low concentrations but is dimeric above 0.1 mg/ml. At i ...
1999The pore-forming toxin proaerolysin is activated by furin
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
Aerolysin is secreted as an inactive dimeric precursor by the bacterium Aeromonas hydrophila. Proteolytic cleavage within a mobile loop near the C terminus of the protoxin is required for oligomerization and channel formation. This loop contains the sequen ...
1998A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
In this paper, we have investigated the effects of the pore-forming toxin aerolysin, produced by Aeromonas hydrophila, on mammalian cells. Our data indicate that the protoxin binds to an 80-kD glycosyl-phosphatidylinositol (GPI)-anchored protein on BHK cel ...
1998