Concept
Antimineralocorticoid
Related publications (25)
Genetic selection for low glucocorticoid responsiveness recapitulates PTSD-related phenotypes: a behavioral, neuroimaging and sleep-physiology study
Humans show inter-individual differences in vulnerability to develop post-traumatic stress disorder (PTSD) following exposure to trauma. Several critical biobehavioral features have been consistently described in PTSD patients, including blunted cortisol l ...
EPFL2022Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination
Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Meltem Weger
Social rank is frequently established through aggressive encounters between new conspecifics. Despite increasing evidence suggesting that social rank is critical for the well-being of both humans and animals, knowledge about the factors influencing social ...
2018Probing the Photosensitizing and Inhibitory Effects of Dissolved Organic Matter by Using N,N-dimethyl-4-cyanoaniline (DMABN)
Urs von Gunten, Frank Jonathan Leresche, Silvio Canonica
Dissolved organic matter (DOM) can act as a photosensitizer and an inhibitor in the phototransformation of several nitrogen-containing organic contaminants in surface waters. The present study was performed to select a probe molecule that is suitable to me ...
American Chemical Society2016Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders
Grégoire Courtine, Quentin Barraud, Pavel Musienko
The invention relates to the selective targeting of specific α2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in a subject affected by spinal cord disorders, in particular spinal cord injury. In particular, the impro ...
2016Cyclin D1 Enhances the Response to Estrogen and Progesterone by Regulating Progesterone Receptor Expression
Estrogen and progesterone are the defining hormones of normal female development, and both play critical roles in breast carcinogenesis. Cyclin D1 is a breast cancer oncogene whose amplification is linked to poor prognosis in estrogen and progesterone rece ...
American Society for Microbiology2010Conditional gene targeting of the ENaC subunit genes Scnn1b and Scnn1g
Friedrich Beermann, Roch-Philippe Charles
Epithelial sodium channels (ENaC) are members of the degenerin/ENaC superfamily of non-voltage-gated, highly amiloride-sensitive cation channels that are composed of three subunits (alpha-, beta- and gamma- ENaC). Since complete gene inactivation of the be ...
2009Individual differences in anxiety trait are related to spatial learning abilities and hippocampal expression of mineralocorticoid receptors
Although high levels of anxiety might be expected to negatively influence learning and memory, it remains to be shown whether individual differences in anxiety may influence spatial learning and memory in outbred rat populations. We have studied this possi ...
2006Astrocytes generate Na+-mediated metabolic waves
Pierre Magistretti, Yann Bernardinelli, Jean-Yves Chatton
Glutamate-evoked Na+ increase in astrocytes has been identified as a signal coupling synaptic activity to glucose consumption. Astrocytes participate in multicellular signaling by transmitting intercellular Ca2+ waves. Here we show that intercellular Na+ w ...
2004Chronic restraint stress induces an isoform-specific regulation on the neural cell adhesion molecule in the hippocampus
Existing evidence indicates that 21-days exposure of rats to restraint stress induces dendritic atrophy in pyramidal cells of the hippocampus. This phenomenon has been related to altered performance in hippocampal-dependent learning tasks. Prior studies ha ...
2002Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease
The ability to regulate gene expression constitutes a prerequisite for the development of gene therapy strategies aimed at the treatment of neurologic disorders. In the present work, we used tetracycline (Tet)-regulated lentiviral vectors to investigate th ...
2002