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The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to pr ...
Empirical evidence suggests that there exists substantial heterogeneity in individuals' social preferences. However, there is little theoretical basis supporting this observation and economic models often assume that all individuals are identical. Hence, t ...
Why do individuals make different decisions when confronted with similar choices? This paper investigates whether the answer lies in an evolutionary process. Our analysis builds on recent work in evolutionary game theory showing the superiority of a given ...
This paper studies natural organisms and plants along with their features that can be utilized to formulate better design-strategies for climate responsive buildings. The conventional buildings are often far away from the concept of sustainability. Bio-mim ...
Paul Scherrer Institute, World Resources Forum2019
Evolution can be described as the change of allele frequencies over time. Four forces - mutation, migration, genetic drift, and selection, drive this change. The aim of my thesis was to accurately estimate and differentiate the parameters governing each of ...
By combining well-established population genetic theory with high-throughput sequencing data from natural populations, major strides have recently been made in understanding how, why, and when vertebrate populations evolve crypsis. Here, we focus on backgr ...
Natural populations present an abundant genetic variability. Like mutation or natural se- lection, dierent processes are at stake to generate this variability. Population genetics is a topic that emerged in the late 40's, thanks mainly to the biologists Fi ...
The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early or ...
This thesis consists of five papers published in peer-reviewed journals, two of which focus on method development of time-serial inference, represented by publications in methodology journals, and three others that describe collaborative data applications ...
Protein structure is tightly intertwined with function according to the laws of evolution. Understanding how structure determines function has been the aim of structural biology for decades. Here, we have wondered instead whether it is possible to exploit ...
