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By combining well-established population genetic theory with high-throughput sequencing data from natural populations, major strides have recently been made in understanding how, why, and when vertebrate populations evolve crypsis. Here, we focus on backgr ...
The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to pr ...
The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early or ...
Protein structure is tightly intertwined with function according to the laws of evolution. Understanding how structure determines function has been the aim of structural biology for decades. Here, we have wondered instead whether it is possible to exploit ...
This paper studies natural organisms and plants along with their features that can be utilized to formulate better design-strategies for climate responsive buildings. The conventional buildings are often far away from the concept of sustainability. Bio-mim ...
Paul Scherrer Institute, World Resources Forum2019
This thesis consists of five papers published in peer-reviewed journals, two of which focus on method development of time-serial inference, represented by publications in methodology journals, and three others that describe collaborative data applications ...
Evolution can be described as the change of allele frequencies over time. Four forces - mutation, migration, genetic drift, and selection, drive this change. The aim of my thesis was to accurately estimate and differentiate the parameters governing each of ...
A recent analysis of evolutionary rates in >500 globular soluble enzymes revealed pervasive conservation gradients toward catalytic residues. By looking at amino acid preference profiles rather than evolutionary rates in the same data set, we quantified th ...
Functional magnetic resonance imaging is a galvanizing tool for behavioral scientists. It provides a means by which to see what the brain does while a person thinks, acts, or perceives, without invasive procedures. In this, fMRI affords us a relatively eas ...
Empirical evidence suggests that there exists substantial heterogeneity in individuals' social preferences. However, there is little theoretical basis supporting this observation and economic models often assume that all individuals are identical. Hence, t ...