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In mammalian tissues, circadian gene expression can be driven by local oscillators or systemic signals controlled by the master pacemaker in the suprachiasmatic nucleus. We show that simulated body temperature cycles, but not peripheral oscillators, contro ...
American Association for the Advancement of Science2012
Complex brain diseases and neurological disorders in human generally result from the disturbance of multiple genes and signaling pathways. These disturbances may derive from mutations, deletions, translocations or rearrangements of specific gene(s). Howeve ...
This chapter discusses the epigenetics of brain disorders. Epigenetic mechanisms play a pivotal role in higher-order brain functions under physiological and pathological conditions. A deeper understanding of these mechanisms is of utmost importance for the ...
Epigenetic mechanisms are not only essential for biological functions requiring stable molecular changes such as the establishment of cell identity and tissue formation, they also constitute dynamic intracellular processes for translating environmental sti ...
A review. Histone deacetylase inhibitors are an emerging class of antiproliferative agents that have the potential to combat cancer on an epigenetic level. The recently reported marine natural product largazole was recently isolated in trace amts. from cya ...
Dry, compression molded films of medical grade poly-L-lactide (PLLA) showed a marked reduction in tensile strength and strain after accelerated ageing in aqueous NaOH at 50 degrees C. accompanied by mass loss, surface erosion, increased hydrophilicity and, ...
Epigenetic alterations during tumor formation and progression have become an increasingly important aspect of cancer biology. Loss of global methylation at histone H4 lysine 20, mediated by the Suv4-20 HMTases, and loss of methylation at histone H3 lysine ...
Objectives: Sixty three healthy subjects were measured to assess dependence of brain metabolites on age using short- and long echo time spectroscopy in different brain regions. Material and methods: Younger and elderly humans were measured with long echo t ...
The skin is privileged because several skin-derived stem cells (epithelial stem cells from epidermis and its appendages, mesenchymal stem cells from dermis and subcutis, melanocyte stem cells) can be efficiently captured for therapeutic use. Main indicatio ...
Over the past decade, it has become increasingly obvious that epigenetic mechanisms are an integral part of a multitude of brain functions that range from the development of the nervous system over basic neuronal functions to higher order cognitive process ...