Concept

Folding@home

Related publications (174)

Extending the concept of template-assembled synthetic proteins

A review with 56 refs. The creation of native-like macromols. in copying nature's way represents a fascinating challenge in protein chem. today. In the absence of detailed knowledge of the complex folding pathway, the ultimate goal in protein de novo desig ...

1999

Solid-phase strategies for the assembly of template-based protein mimetics

The template concept for overcoming the protein folding problem in protein de novo design has recently been extended for mimicking essential structural and functional features of proteins. Due to progress in synthetic methodologies, template-assembled cons ...

1999

Protein design: on the threshold of functional properties

A review with several refs. The ultimate goal in protein de novo design is the creation of novel macromols. with tailor-made receptor, sensory, and catalytic functions. Despite considerable progress in understanding basic rules of secondary structure forma ...

1998

Ferredoxin Reduction by Photosystem I fromSynechocystissp. PCC 6803: Toward an Understanding of the Respective Roles of Subunits PsaD and PsaE in Ferredoxin Binding

Patrick Daniel Barth

The process of ferredoxin reduction by photosystem I has been extensively investigated by flash-absorption spectroscopy in psaD and psaE deleted mutants from Synechocystis sp. PCC 6803. In both mutants, the dissociation constant for the photosystem I/ferre ...

1998

Engineering of zinc finger and MHC motifs to locked-in tertiary folds

Christian Lehmann

The assembly of helical and b-sheet peptide blocks contg. reactive chain ends results in highly branched chain architectures ("locked-in folds") mimicking native tertiary structures. This mol. kit strategy allows to bypass the protein folding problem in ...

1997

Non-native architectures in protein design and mimicry

A review is given with 62 refs. on the art of template-based protein de novo design, with special emphasis on progress in peptide synthesis and template design and show that some fundamental questions in protein assembly, structure and function can be appr ...

1997

Theoretical study of a five-coordinated silica polymorph

Philippe Gillet, James Badro

Theoretical calculations are performed to study transformations in silica as a function of nonhydrostatic stress. Molecular-dynamics calculations reveal a crystalline-to-crystalline transition from alpha-quartz to a phase with five-coordinated silicon (Si- ...

1997

Silicon Micro/Nanomechanical Device Fabrication Based on Focused Ion Beam Surface Modification and KOH Etching

Jürgen Brugger

Selective Ga + ion implantation and miring by focused ion beam exposure and subsequent wet chemical etching is used to fabricate micro/nanomechanical elements in Si. Freestanding elements with a ~ 30 nm membrane thickness are made by controlled selective u ...

1997

Halogenated analogs of the antimalarial bialamicol

In a successful attempt to amplify the pharmacol. activity of the antimalarial bialamicol, substituents were introduced in the 2-position of the allyl side chains. 2-Fluoroallyl bromide, a versatile C3F building block, is described for the first time. Whil ...

1996

Protein de novo design

A review with 43 refs. on strategies for the synthesis of protein mimetics and artificial proteins. The ultimate goal in protein de novo design is the construction of artificial proteins inhibiting tailor-made structural and functional properties. To creat ...

1996

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