Publications related to Insulator (genetics)

Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

Since Strahl and Allis proposed the "language of covalent histone modifications", a host of experimental studies have shed light on the different facets of chromatin regulation by epigenetic mechanisms. Initially proposed as a concept for controlling gene ...

Academic Press Ltd- Elsevier Science Ltd2024

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

Denis Duboule, Lucille Delisle, Alexandre Gauthier Aurèle Mayran, Hocine Rekaik, Aurélie Hintermann, Célia Corinne Renée Bochaton

Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed tr ...

NATURE PORTFOLIO2023

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

Beat Fierz, Wei Cai, Harsh Nagpal

Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A. Contacting CENP-A nucleosomes, the constitutive centromere associated network (CCAN) and the kinetochore assemble, connecting the centromere to spindle microtubules d ...

Berlin2023

Essential role of Cp190 in physical and regulatory boundary formation

Nicolas Jean Philippe Guex, Julien Dorier, Christian Iseli

Boundaries in animal genomes delimit contact domains with enhanced internal contact frequencies and have debated functions in limiting regulatory cross-talk between domains and guiding enhancers to target promoters. Most mammalian boundaries form by stalli ...

2022

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Freddy Radtke, Ute Koch, Nadine Fournier, Marianne Nkosi, Christelle Dubey, Mateusz Waldemar Antoszewski, Tara Kimberly Sugrue, Giovanni Ciriello

NOTCH1 is a well-established lineage specifier for T cells and among the most frequently mutated genes throughout all subclasses of T cell acute lymphoblastic leukemia (T-ALL). How oncogenic NOTCH1 signaling launches a leukemia-prone chromatin landscape du ...

AMER SOC HEMATOLOGY2022

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

Denis Duboule, Lucille Delisle, Jozsef Zakany, Leonardo Beccari

In this study, Amandio et al. sought to understand the functions of the highly conserved CTCF sites distributed over the Hox gene clusters. The authors produced an allelic series of cumulative in cis mutations in these sites, up to the abrogation of CTCF b ...

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2021

CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions

Nicolas Jean Philippe Guex, Julien Dorier, Christian Iseli, Flavia Marzetta

Vertebrate genomes are partitioned into contact domains defined by enhanced internal contact frequency and formed by two principal mechanisms: compartmentalization of transcriptionally active and inactive domains, and stalling of chromosomal loop-extruding ...

2021

Damage-driven strain localisation in networks of fibres: A computational homogenisation approach

Pablo Antolin Sanchez, Felipe Figueredo Rocha

In many applications, such as textiles, fibreglass, paper and several kinds of biological fibrous tissues, the main load-bearing constituents at the micro-scale are arranged as a fibre network. In these materials, rupture is usually driven by micro-mechani ...

2021

Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle

Felix Naef, Jake Yeung, Jérôme Mermet

The circadian clock drives extensive temporal gene expression programs controlling daily changes in behavior and physiology. In mouse liver, transcription factors dynamics, chromatin modifications, and RNA Polymerase II (PolII) activity oscillate throughou ...

2021

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Insulator (genetics)

Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

Whole genome doubling promotes tumorigenesis through loss of chromatin segregation and compartment repositioning

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

Essential role of Cp190 in physical and regulatory boundary formation

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions

Damage-driven strain localisation in networks of fibres: A computational homogenisation approach

Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle

Graph Chatbot

Chat with Graph Search

Whole genome doubling promotes tumorigenesis through loss of chromatin segregation and compartment repositioning

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle

Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

Essential role of Cp190 in physical and regulatory boundary formation

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

Damage-driven strain localisation in networks of fibres: A computational homogenisation approach

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions