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The present invention relates to methods of transferring a label from novel substrates to O-alkylguanine-DNA alkyltransferases (AGT) and O-alkylguanine-DNA alkyltransferase fusion proteins, and to novel substrates suitable in such methods. Proteins o ...
The present invention relates to methods of transferring a label from suitable substrates to O6-alkylguanine-DNA alkyltransferase (AGT) fusion proteins, to suitable fusion proteins, to suitable variants of AGT, and to novel labelled fusion proteins obtaine ...
The increasing complexity of nowadays applications has lead to the need of more and more intensive specification and validation tasks by means of software implementations. Besides, as the complexity grows, it is becoming very hard to understand the specifi ...
Using multiple contexts improves model understandability and contributes to solving a scalability problem. In our work, we introduce a modeling method called Systemic Enterprise Architecture Methodology (SEAM) that considers systems to be designed in diffe ...
Comparative Performance Analysis of Ordering Strategies in Atomic Broadcast Algorithms Xavier Defago, Andre Schiper, Peter Urban In this paper, we present the results of a comparative analysis of Atomic Broadcast algorithms. The analysis was done by using ...
Nature abounds in examples of cellular systems. From ant colonies to cellular tissues, from molecular systems to the human brain, cellularity seems to be the way Nature operates. The brain, surely one of the most complex objects to be found on earth, is th ...
This report represents the work of several people within the framework of the StreamCom project. This work, done together with our colleges from the University of St. Gallen, covers the modeling part of StreamCom. The aim of the modeling part of the Stream ...
The optical properties of mols. in complex environments were studied within hybrid time-dependent d. functional theory / mol. mechanics (TDDFT/MM) simulation studies. The potential energy surface in the excited state is described within time-dependent d. f ...
O6-substituted guanine derivs. are described for use as substrates for O6-alkylguanine-DNA alkyltransferases (AGT) that can be used to label the enzyme or fusion proteins contg. it. Proteins of interest are incorporated into an AGT fusion protein, the AGT ...
(Ecole Polytechnique Federale de Lausanne (EPFL), Switz.).2004
The present invention relates to methods of transferring a label from suitable substrates to O6-alkylguanine-DNA alkyltransferase (AGT) fusion proteins, to suitable fusion proteins, to suitable variants of AGT, and to novel labeled fusion proteins obtained ...
(Ecole Polytechnique Federale de Lausanne (EPFL), Switz.).2004