Concept
Circumventricular organs
Related publications (32)
CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection
Ludovic Pierre Gustave Keiser, Laura Desban
The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether and how sensory cells in the central nervous system (CNS) become activated during bacteri ...
CELL PRESS2023Axonal projections from mouse whisker-related sensory cortex
Neurons primarily communicate through release of neurotransmitter from presynaptic specialisations along their axonal arborisations. In order to understand the functional role of a specific neuron, it is therefore of great interest to know the structure of ...
EPFL2023Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of the SMN1 gene and low SMN protein levels. Although lower motor neurons are a primary target, there is evidence that peripheral organ defects contribute to SMA. Current SMA gene ther ...
2022A method to establish functional vagus nerve topography from electro-neurographic spontaneous activity
Silvestro Micera, Simone Romeni
Bioelectronic medicine is an emerging approach to treat many types of diseases via electrical stimulation of the autonomic nervous system (ANS). Because the vagus nerve (VN) is one of the most important nerves controlling several ANS functions, stimulation ...
2022New Insights Into the Pivotal Role of CREB-Regulated Transcription Coactivator 1 in Depression and Comorbid Obesity
Antoine Timothée Cherix, Jean-René Cardinaux
Depression and obesity are major public health concerns, and there is mounting evidence that they share etiopathophysiological mechanisms. The neurobiological pathways involved in both mood and energy balance regulation are complex, multifactorial and stil ...
FRONTIERS MEDIA SA2022Development of a Transient Neural Interface for Minimally Invasive Recording and Stimulation
Transient electronics enabling devices to safely disappear in the environment can be applied not only in green electronics, but also in bioelectronic medicine. Neural implants able to degrade harmlessly inside the body eliminate the need for removal surger ...
EPFL2022The role of medial amygdala inhibitory neurons in regulating social behavior
Aggression is an evolutionary conserved social behavior that is necessary for an animalÂŽs survival. The neural substrates coordinating aggression are known to exist in the amygdala and the hypothalamus. While the medial amygdala (MeA) and the ventrolatera ...
EPFL2021Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome
Mutations in nuclear-encoded mitochondrial genes are responsible for a broad spectrum of disorders among which Leigh syndrome is the most common in infancy. No effective therapies are available for this severe disease mainly because of the limited capabili ...
2020Gene expression across mammalian organ development
Maria del Carmen Sandi Perez, Ioannis Xenarios
The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early or ...
2019