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Concept
Aphthovirus
Summary
Aphthovirus (from the Greek -, vesicles in the mouth) is a viral genus of the family Picornaviridae. Aphthoviruses infect split-hooved animals, and include the causative agent of foot-and-mouth disease, Foot-and-mouth disease virus (FMDV). There are seven FMDV serotypes: A, O, C, SAT 1, SAT 2, SAT 3 and Asia 1, and four non-FMDV serotypes belonging to three additional species Bovine rhinitis A virus (BRAV), Bovine rhinitis B virus (BRBV) and Equine rhinitis A virus (ERAV).
Aphthoviruses are non-enveloped and have an icosahedral capsid with a diameter of around 27 to 30 nm. The assembled viral capsid contains a single copy of the RNA genome and 60 copies of the four viral capsid proteins VP1, VP2, VP3, and VP4. The protomers form the sides of the icosahedral capsid. The VP4 protein is internal.
The aphthoviruses are differentiated from other picornaviruses as they have a larger genome (7.5–8.5 kilobases). The genome is non-segmented and consists of a positive-sense single-stranded RNA. It contains a single open reading frame with a 5' end linked protein (VPg), which is associated with the genome via a phosphodiester bond linked to a tyrosine residue. The 5' untranslated region (UTR) of the genome contains a poly(C) tract and an internal ribosome entry site (IRES), while the 3' UTR is polyadenylated. The P1 region encodes the structural proteins. The P2 and P3 regions encode the nonstructural proteins associated with replication.
Aphthoviruses replicate in a similar fashion to all picornaviruses. Replication is cytoplasmic and initially involves attachment of the exogenous virus to the cell membrane. Attachment to the membrane and subsequent entry into the cell is mediated by a membrane receptor. After genome replication within the cytoplasm, virion assembly occurs and new virus particles aggregate within the cell. Release of virus particles is mediated by cell lysis.
The aphthovirus RNA genome is able to undergo genetic recombination. Recombination occurs at a large number of genomic sites indicating that RNA recombination in aphthovirus is a general, rather than a site specific, phenomenon.
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