Concept

Cilium

Related publications (80)

Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow

Thomas Alois Weber, Daniel Constam, Charlotte Maisonneuve

Polycystic diseases and left-right (LR) axis malformations are frequently linked to cilia defects. Renal cysts also arise in mice and frogs lacking Bicaudal C (BicC), a conserved RNA-binding protein containing K-homology (KH) domains and a sterile alpha mo ...

2009

Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal

Daniel Constam

A fundamental challenge in biology is to explain how progenitor cells in developing tissues acquire distinct fates according to their position. In vertebrates, the positional information that specifies the germ layers and the primary body axes is mediated ...

Elsevier2009

Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model

Melody Swartz, Alice Anna Tomei

Asthmatic patients are more susceptible to viral infection, and we asked whether dynamic strain on the airway wall (such as that associated with bronchoconstriction) would influence the rate of viral infection of the epithelial and subepithelial cells. To ...

2008

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

Daniel Constam, Stéphane Baflast

The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described. We show that Cripto also binds the ...

2008

Cripto localizes nodal at the limiting membrane of early endosomes

Daniel Constam, Stéphane Baflast

Cripto is a glycosylphosphatidylinositol (GPI)-anchored co-receptor of Nodal and several other transforming growth factor-beta (TGF-beta) family ligands. It contains an epidermal growth factor (EGF)-like motif and a Cripto-FRL1-Cryptic (CFC) domain, which ...

2008

Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types

Friedrich Beermann, Anne Grapin-Botton

All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated tran ...

2007

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans

Henning Paul-Julius Stahlberg

The diversity of sensory cilia on Coenorhabditis elegans neurons allows the animal to detect a variety of sensory stimuli. Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport ciliary precursors, bound to IFT particles, a ...

Rockefeller University Press2006

The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4

Luca Pescatore, Felix Naef, Daniel Constam

During early mouse development, the subtilisin-like proprotein convertases (SPC) Furin and PACE4 pattern the primitive ectoderm and visceral endoderm, presumably by activating the TGFss-related Nodal precursor. Here, mutation of the SPC motif provides dire ...

2006

Nodal stability determines signaling range

Daniel Constam, Yixing Chen

Secreted TGFbeta proteins of the Nodal family pattern the vertebrate body axes and induce mesoderm and endoderm . Nodal proteins can act as morphogens , but the mechanisms regulating their activity and signaling range are poorly understood. In particular, ...

2005

C. elegans tubby regulates life span and fat storage by two independent mechanisms

Bart Deplancke

In C. elegans, similar to in mammals, mutations in the tubby homolog, tub-1, promote increased fat deposition. Here, we show that mutation in tub-1 also leads to life span extension dependent on daf-16/FOXO. Interestingly, function of tub-1 in fat storage ...

2005

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