Publications related to Geriatrics

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Johan Auwerx, Pénélope Andreux, Davide D'Amico, Pamela Solange Valdés Undurraga, Anurag Singh

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its ...

2021

Gamified Motor Training With Tangible Robots in Older Adults: A Feasibility Study and Comparison With the Young

Pierre Dillenbourg, Friedhelm Christoph Hummel, Wafa Monia Benkaouar Johal, Maximilian Jonas Wessel, Ayberk Özgür, Jennifer Kaitlyn Olsen

Background: An increasing lifespan and the resulting change in our expectations of later life stages are dependent on a good health state. This emphasizes the importance of the development of strategies to further strengthen healthy aging. One important as ...

2020

Age-Dependent Asymmetry of Wrist Position Sense Is Not Influenced by Stochastic Tactile Stimulation

Jamie Paik, Olivier Lambercy, Harshal Arun Sonar

Stochastic stimulation has been shown to improve movement, balance, the sense of touch, and may also improve position sense. This stimulation can be non-invasive and may be a simple technology to enhance proprioception. In this study, we investigated wheth ...

2020

Recommender System for Responsive Engagement of Senior Adults in Daily Activities

Pearl Pu Faltings, Igor Kulev, Yuan Lu

Understanding and predicting how people change their behavior after an intervention from time series data is an important task for health recommender systems. This task is especially challenging when the time series data is frequently sampled. In this pape ...

SPRINGER INTERNATIONAL PUBLISHING AG2020

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice

Johan Auwerx, Jun Yong Kim, Dongryeol Ryu, Ludger Jan Elzuë Goeminne

Mitochondrial dysfunction is associated with aging-mediated inflammatory responses, leading to metabolic deterioration, development of insulin resistance, and type 2 diabetes. Growth differentiation factor 15 (GDF15) is an important mitokine generated in r ...

2020

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Johan Auwerx, Patrick Aebischer, Pénélope Andreux, Dongryeol Ryu, Frederic Burdet, Anurag Singh

Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging(1). Here, we report the results of a first-in-human clinical trial in which we adm ...

NATURE PUBLISHING GROUP2019

Vitamin B12 deficiency and impaired expression of amnionless during aging

Sonia Karaz, Laurence Goulet, Alice Pannerec

Background Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. Vitamin B12 deficiency has been linked to several age-related chronic diseases, including in the musculo-skeleta ...

2018

Stability against backward balance loss: Age-related modifications following slip-like perturbations of multiple amplitudes

Silvestro Micera

Falls are one of the most serious problems in the elderly. Although previous studies clearly link the increased risk of falls with ageing, the mechanisms responsible for the modifications of reactive motor behaviours in response to external perturbations a ...

Elsevier Ireland Ltd2017

An ecologically-controlled exoskeleton can improve balance recovery after slippage

Silvestro Micera

The evolution to bipedalism forced humans to develop suitable strategies for dynamically controlling their balance, ensuring stability, and preventing falling. The natural aging process and traumatic events such as lower-limb loss can alter the human abili ...

Nature Publishing Group2017

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Geriatrics

Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Gamified Motor Training With Tangible Robots in Older Adults: A Feasibility Study and Comparison With the Young

Age-Dependent Asymmetry of Wrist Position Sense Is Not Influenced by Stochastic Tactile Stimulation

Recommender System for Responsive Engagement of Senior Adults in Daily Activities

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Vitamin B12 deficiency and impaired expression of amnionless during aging

Stability against backward balance loss: Age-related modifications following slip-like perturbations of multiple amplitudes

An ecologically-controlled exoskeleton can improve balance recovery after slippage

Graph Chatbot

Chat with Graph Search

Age-Dependent Asymmetry of Wrist Position Sense Is Not Influenced by Stochastic Tactile Stimulation

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Vitamin B12 deficiency and impaired expression of amnionless during aging

Recommender System for Responsive Engagement of Senior Adults in Daily Activities

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice

Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease

Stability against backward balance loss: Age-related modifications following slip-like perturbations of multiple amplitudes

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

An ecologically-controlled exoskeleton can improve balance recovery after slippage

Gamified Motor Training With Tangible Robots in Older Adults: A Feasibility Study and Comparison With the Young