Concept

DNA profiling

Related publications (219)

The emergence of nanopores in next-generation sequencing

Aleksandra Radenovic, Lorenz Jan Steinbock

Next-generation sequencing methods based on nanopore technology have recently gained considerable attention, mainly because they promise affordable and fast genome sequencing by providing long read lengths (5 kbp) and do not require additional DNA amplific ...

2015

DNA Transport across the Outer and Inner Membranes of Naturally Transformable Vibrio cholerae Is Spatially but Not Temporally Coupled

Melanie Blokesch, Patrick Martin Seitz

The physiological state of natural competence for transformation allows certain bacteria to take up free DNA from the environment and to recombine such newly acquired DNA into their chromosomes. However, even though conserved components that are required t ...

American Society for Microbiology2014

Engineering chromatin states: Chemical and synthetic biology approaches to investigate histone modification function

Beat Fierz, Horst Pick, Sinan Kilic

Patterns of histone post-translational modifications (PTMs) and DNA modifications establish a landscape of chromatin states with regulatory impact on gene expression, cell differentiation and development. These diverse modifications are read out by effecto ...

Elsevier Science Bv2014

ComEA Is Essential for the Transfer of External DNA into the Periplasm in Naturally Transformable Vibrio cholerae Cells

Aleksandra Radenovic, Matteo Dal Peraro, Melanie Blokesch, Lorenz Jan Steinbock, Roman Bulushev, Patrick Martin Seitz, Hasan Pezeshgi Modarres

The DNA uptake of naturally competent bacteria has been attributed to the action of DNA uptake machineries resembling type IV pilus complexes. However, the protein(s) for pulling the DNA across the outer membrane of Gram-negative bacteria remain speculativ ...

Public Library Science2014

Composition of the DNA-uptake complex of Vibrio cholerae

Melanie Blokesch, Lisa Christina Metzger

Natural competence for transformation is a developmental program that allows certain bacteria to take up free extracellular DNA from the environment and integrate this DNA into their genome. Thereby, natural transformation acts as mode of horizontal gene t ...

2014

Automated long-term single cell analysis of Schizosaccharomyces pombe on a microfluidic microchemostat array

Jean-Bernard Nobs

How cells grow and divide is a question that was raised more than 100 years ago. Despite years of research and in-depth knowledge of several molecular mechanisms, the complete system that regulates and coordinates both of those activities within Schizosacc ...

EPFL2014

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

Andrea Ablasser

Cytosolic detection of DNA is crucial for the initiation of antiviral immunity but can also cause autoimmunity in the context of endogenous nucleic acids being sensed. Mutations in the human 3' repair exonuclease 1 (TREX1) have been linked to the type I IF ...

2014

Toward Vibrational Dynamics at Liquid-Liquid and Nano-Interfaces: Time-Resolved Sum-Frequency Scattering

Sylvie Roke, Rüdiger Scheu

Interfacial molecular dynamics are key to understanding many phenomena in technology and life sciences. We demonstrate a first step toward accessing vibrational dynamics at liquid-liquid and nanoscopic (bio)-interfaces using time-resolved sum-frequency sca ...

American Chemical Society2014

Comment une situation d’investigation policière fait évoluer les conceptions d’élèves de troisième sur l’ADN

The work presented focuses on the analysis of a police investigation implemented in the computing environment SCY-Lab. The prime objective is to check if the implementation of the situation helps pupils change their conceptions concerning the DNA molecule ...

2013

Detecting the translocation of DNA through a nanopore using graphene nanoribbons

Aleksandra Radenovic, Andras Kis, Ke Liu, Daria Krasnozhon, Camille Alice Raillon, Floriano Traversi, Mohamed Malik Benameur, Sergey Khlybov

Solid-state nanopores can act as single-molecule sensors and could potentially be used to rapidly sequence DNA molecules. However, nanopores are typically fabricated in insulating membranes that are as thick as 15 bases, which makes it difficult for the de ...

Nature Publishing Group2013

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