Concept

Sirtuin

Related publications (69)

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

Protein acetylation, which is central to transcriptional control as well as other cellular processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation levels, such as inhibiting histone deacetylases (HDACs), are effecti ...

Oxford University Press2014

Regulation of Energy Metabolism and Mitochondrial Function in Skeletal Muscle During Lipid Overfeeding in Healthy Men

Context/Objective: The aim of this study was to evaluate the regulation of the fuel partitioning and energy metabolism in skeletal muscle during lipid overfeeding in healthy men. Design/Participants/Intervention: Thirty-nine healthy volunteers were overfed ...

Endocrine Soc2014

Metabolic Characterization of a Sirt5 deficient mouse model

Johan Auwerx, Kristina Schoonjans, Norman Lionel Moullan, Lilia Noriega Lopez, Jiujiu Yu

Sirt5, localized in the mitochondria, is a member of sirtuin family of NAD(+)-dependent deacetylases. Sirt5 was shown to deacetylate and activate carbamoyl phosphate synthase 1. Most recently, Sirt5 was reported to be the predominant protein desuccinylase ...

Nature Publishing Group2013

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis

NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD(+) levels results in a further red ...

Cell Press2013

A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

Johannes Gräff

Caloric restriction (CR) is a dietary regimen known to promote lifespan by slowing down the occurrence of age-dependent diseases. The greatest risk factor for neurodegeneration in the brain is age, from which follows that CR might also attenuate the progre ...

Society for Neuroscience2013

Hdac6 deletion delays disease progression in the SOD1(G93A) mouse model of ALS

Johan Auwerx

Defects in axonal transport are thought to contribute to the pathogenesis of neurodegenerative disease. Because -tubulin acetylation facilitates axonal transport, inhibition of the -tubulin deacetylating enzymes, histone deacetylase 6 (Hdac6) and silent in ...

Oxford University Press2013

HDAC4 Does Not Act as a Protein Deacetylase in the Postnatal Murine Brain In Vivo

Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. It is governed by the antagonistic commitment of two enzymes families: the histone acetyltransferases (HATs) and the histone deacetyl ...

Public Library Science2013

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

Johan Auwerx, Julien Weber, Yuan Liu, Chad Brokopp

Sirt3 is a mitochondrial NAD(+)-dependent deacetylase that governs mitochondrial metabolism and reactive oxygen species homeostasis. Sirt3 deficiency has been reported to accelerate the development of the metabolic syndrome. However, the role of Sirt3 in a ...

Springer Verlag2013

Sirtuins as regulators of metabolism and healthspan

Johan Auwerx, Richardus Houtkooper, Eija Riitta Pirinen

Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histon ...

2012

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD(+)?

Johan Auwerx, Carlos Canto Alvarez

Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD(+)-dependent deacetylase that is at the pinnacle of metabolic control, all the way from yeast to humans. SIRT1 senses changes in intracellular NAD(+) levels, which reflect energy level, and uses this inf ...

2012

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