A cyclotron is a type of particle accelerator invented by Ernest Lawrence in 1929–1930 at the University of California, Berkeley, and patented in 1932. A cyclotron accelerates charged particles outwards from the center of a flat cylindrical vacuum chamber along a spiral path. The particles are held to a spiral trajectory by a static magnetic field and accelerated by a rapidly varying electric field. Lawrence was awarded the 1939 Nobel Prize in Physics for this invention.
The cyclotron was the first "cyclical" accelerator. The primary accelerators before the development of the cyclotron were electrostatic accelerators, such as the Cockcroft–Walton generator and the Van de Graaff generator. In these accelerators, particles would cross an accelerating electric field only once. Thus, the energy gained by the particles was limited by the maximum electrical potential that could be achieved across the accelerating region. This potential was in turn limited by electrostatic breakdown to a few million volts. In a cyclotron, by contrast, the particles encounter the accelerating region many times by following a spiral path, so the output energy can be many times the energy gained in a single accelerating step.
Cyclotrons were the most powerful particle accelerator technology until the 1950s, when they were surpassed by the synchrotron. Nonetheless they are still widely used to produce particle beams for nuclear medicine and basic research. As of 2020, close to 1,500 cyclotrons were in use worldwide for the production of radionuclides for nuclear medicine. In addition, cyclotrons can be used for particle therapy, where particle beams are directly applied to patients.
In late 1928 and early 1929, Hungarian physicist Leo Szilárd filed patent applications in Germany for the linear accelerator, cyclotron, and betatron. In these applications, Szilárd became the first person to discuss the resonance condition (what is now called the cyclotron frequency) for a circular accelerating apparatus.
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A particle accelerator is a machine that uses electromagnetic fields to propel charged particles to very high speeds and energies, and to contain them in well-defined beams. Large accelerators are used for fundamental research in particle physics. The largest accelerator currently active is the Large Hadron Collider (LHC) near Geneva, Switzerland, operated by the CERN. It is a collider accelerator, which can accelerate two beams of protons to an energy of 6.5 TeV and cause them to collide head-on, creating center-of-mass energies of 13 TeV.
A gamma ray, also known as gamma radiation (symbol γ or ), is a penetrating form of electromagnetic radiation arising from the radioactive decay of atomic nuclei. It consists of the shortest wavelength electromagnetic waves, typically shorter than those of X-rays. With frequencies above 30 exahertz (3e19Hz), it imparts the highest photon energy. Paul Villard, a French chemist and physicist, discovered gamma radiation in 1900 while studying radiation emitted by radium.
Nuclear medicine or nucleology is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease. Nuclear imaging, in a sense, is "radiology done inside out" because it records radiation emitting from within the body rather than radiation that is generated by external sources like X-rays. In addition, nuclear medicine scans differ from radiology, as the emphasis is not on imaging anatomy, but on the function. For such reason, it is called a physiological imaging modality.
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