Concept
Septic shock
Related publications (33)
Exome Sequencing Reveals Primary Immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis
Jacques Fellay, Istvan Bartha, Samira Asgari, Christoph Berger, Richard Wong
One out of three pediatric sepsis deaths in high income countries occur in previously healthy children. Primary immunodeficiencies (PIDs) have been postulated to underlie fulminant sepsis, but this concept remains to be confirmed in clinical practice. Pseu ...
Frontiers Media Sa2016In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons
Pierre Magistretti, Patrick Aebischer, Bernard Schneider, Sylvain Eric Lengacher, Maha Elsayed
Investigating lactate dynamics in brain tissue is challenging, partly because in vivo data at cellular resolution are not available. We monitored lactate in cortical astrocytes and neurons of mice using the genetically encoded FRET sensor Laconic in combin ...
Cell Press2016Sensing Gram-negative bacteria: a phylogenetic perspective
Gram-negative bacteria represent a major group of pathogens that infect all eukaryotes from plants to mammals. Gram-negative microbe-associated molecular patterns include lipopolysaccharides and peptidoglycans, major immunostimulatory determinants across p ...
Elsevier2016Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila
Bruno Lemaitre, Jean Philippe Boquete, Jan Paul Dudzic, Sveta Chakrabarti, Xiaoxue Li, Esther Jeanne Collas
The JAK/STAT pathway is a key signaling pathway in the regulation of development and immunity in metazoans. In contrast to the multiple combinatorial JAK/STAT pathways in mammals, only one canonical JAK/STAT pathway exists in Drosophila. It is activated by ...
Public Library of Science2016TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb
Michele De Palma, Daniela Biziato
A third of patients with critical limb ischemia (CLI) will eventually require limb amputation. Therapeutic neovascularization using unselected mononuclear cells to salvage ischemic limbs has produced modest results. The TIE2-expressing monocytes/macrophage ...
Wiley-Blackwell2013Role and regulation of the melanization reaction in Drosophila immune response
In arthropods, the melanization reaction consists in the rapid synthesis of melanin at the site of infection and injury. A key enzyme in the melanization process is phenoloxidase (PO), which catalyzes the oxidation of phenols to quinones that subsequently ...
EPFL2013Did Cholera Toxin Finally Get Caught?
Françoise Gisou van der Goot Grunberg
To orchestrate immune responses, pathogen-recognition receptors have evolved sophisticated strategies to monitor pathogenic processes. In this issue of Cell Host & Microbe, a study by Cho et al. reveals a mechanism of immune recognition that relies on the ...
Cell Press2013WhiB5, a Transcriptional Regulator That Contributes to Mycobacterium tuberculosis Virulence and Reactivation
Kai Johnsson, Hirohito Haruki, Monica Rengifo Gonzalez
The proteins belonging to the WhiB superfamily are small global transcriptional regulators typical of actinomycetes. In this paper, we characterize the role of WhiB5, a Mycobacterium tuberculosis protein belonging to this superfamily. A null mutant was con ...
American Society for Microbiology2012Modulation of Dendritic Cells Function by H. polygyrus Products
Dendritic cells (DCs) are crucial antigen-presenting cells that can drastically change the development of an immune response by polarising T helper cells toward a Th1 or a Th2 phenotype. Heligmosomoides polygyrus, a murine model of human helminth, has been ...
2011Ablation of the Tumor Suppressor Histidine Triad Nucleotide Binding Protein 1 is Protective Against Hepatic Ischemia/Reperfusion Injury
The identification of cellular pathways capable of limiting ischemia/reperfusion (I/R) injury remains a frontier in medicine, and its clinical relevance is urgent. Histidine triad nucleotide binding protein 1 (HINT1) is a tumor suppressor that influences a ...
2011