Concept
Asthma
Related publications (32)
Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
Eva Sabrina Gollwitzer, Nicola Harris, Benjamin John Marsland
Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and, consequently, the health or disease of the intestinal tract. However, whether such host-microbe crosstalk influences inflammation in peripheral tissues, such as the ...
Nature Publishing Group2014Identification of airway bacterial colonization by an electronic nose in Chronic Obstructive Pulmonary Disease
Background: Airway bacterial colonization by potentially pathogenic microorganisms occurs in a proportion of patients with Chronic Obstructive Pulmonary Disease (COPD). It increases airway inflammation and influences outcomes negatively. Yet, its diagnosis ...
Elsevier2014Discovery of a low order drug-cell response surface for applications in personalized medicine
Hubert van den Bergh, Patrycja Nowak-Sliwinska, Yiyang Li
The cell is a complex system involving numerous components, which may often interact in a non-linear dynamic manner. Diseases at the cellular level are thus likely to involve multiple cellular constituents and pathways. As some drugs, or drug combinations, ...
Iop Publishing Ltd2014Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway
Background-For reasons that remain unclear, whether type 5 adenylyl cyclase (AC5), 1 of 2 major AC isoforms in heart, is protective or deleterious in response to cardiac stress is controversial. To reconcile this controversy we examined the cardiomyopathy ...
American Heart Association2013NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory ...
Cell Press2013Transcription factor ROR alpha is critical for nuocyte development
Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously ...
2012Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization
Nicola Harris, Benjamin John Marsland, Tina Herbst
RATIONALE: The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora. OBJECTIVES: To ascertain the relevance of commensal bacteria upo ...
2011