Qarshi (Qarshi/Қарши, qarʃɨ; نخشب Nakhshab) is a city in southern Uzbekistan. It is the capital of Qashqadaryo Region. Administratively, Qarshi is a district-level city, that includes the urban-type settlement Qashqadaryo. It has a population of 278,300 (2021 estimate). It is about 520 km south-southwest of Tashkent, and about 335 km north of Uzbekistan's border with Afghanistan. It is located at latitude 38° 51' 48N; longitude 65° 47' 52E at an altitude of 374 meters. The city is important in natural gas production, but Qarshi is also famous for its production of woven flat carpets.
Originally the Sogdian city of Nakhshab (which could be possibly named Eucratideia during the rule of Greco-Bactrian Kingdom), and the Islamic Uzbek (Turkic) city of Nasaf, and the Chagatay city of Qarshi (pronounced Kharsh), Qarshi was the second city of the Emirate of Bukhara. It is in the center of a fertile oasis that produces wheat, cotton, and silk and was a stop on the 11-day caravan route between Balkh and Bukhara. The Mongol Chagataid khans Kebek and Qazan built palaces here on the site of Chinggis Khaan's summer pasture. In 1364, Timur also built a fortified palace with moats in what is now the southern part of the city. The modern name "Qarshi" means fort.
Karshi developed steadily from the 14th century. During the Sheyban dynasty the town grew violently (16th century). It was the second largest town of Bukhara Khanate in the 18th century. During these centuries much of the city's magnificent architectural monuments were built. With the decline of Shahrisabz in the 18th century, Qarshi grew in importance, and was the seat of the Crown Prince to the Emirate of Bukhara. The city had a double set of walls, 10 caravanserais and 4 madrassahs during this time. By 1868, the Russians had annexed the Zarafshan Valley, and in 1873, the treaty turning Bukhara into a Russian protectorate was signed in Qarshi, much to the dismay of the Emir's son, Abdul Malik, who took to the hills in rebellion.