Concept

Nucleic acid hybridization

Related publications (74)

Electronic decoupling of an epitaxial graphene monolayer by gold intercalation

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The application of graphene in electronic devices requires large-scale epitaxial growth. The presence of the substrate, however, usually reduces the charge-carrier mobility considerably. We show that it is possible to decouple the partially sp(3)-hybridize ...

2010

The importance of the photonic mode density in bioassays based on evanescent optical waves

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We have determined limits of detection (LODs) of DNA hybridization using an optical detection by two different method, i.e., surface plasmon fluorescence spectroscopy (SPFS) and optical waveguide fluorescence spectroscopy (OWFS), however, an identical sens ...

2009

The serpin Spn5 is essential for wing expansion in Drosophila melanogaster

Giorgio Margaritondo, Vincent Gajdosik

Serpins, a superfamily of protease inhibitors, control proteolytic cascades in many physiological processes. Genomic studies have revealed the presence of a high number of serpin-encoding genes in Drosophila melanogaster, but their functions remain largely ...

University of the Basque Country Press2008

GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys

Patrick Aebischer

Human neural progenitor cells (hNPCs) have been proposed as a potential source of cells for ex vivo gene therapy. In this pilot study, three 5-year-old female cynomolgus monkeys received a single intracarotid infusion of MPTP, followed 1 week later by MRI- ...

2008

Electroacoustic Polymer Microchip as an Alternative to Quartz Crystal Microbalance for Biosensor Development

Hubert Girault

Laser photoablation of poly(ethylene terephthalate) (PET), a flexible dielectric organic polymer, was used to design an acoustic miniaturized DNA biosensor. The microchip device includes a 100-μm-thick PET layer, with two microband electrodes patterned in ...

2008

Calcium phosphate transfection generates mammalian recombinant cell lines with higher specific productivity than polyfection

Florian Maria Wurm, David Hacker, Madiha Derouazi, Sébastien Chenuet, Nicolas Jaccard

Transfection with polyethylenimine (PEI) was evaluated as a method for the generation of recombinant Chinese hamster ovary (CHO DG44) cell lines by direct comparison with calcium phosphate-DNA coprecipitation (CaPO4) using both green fluorescent protein (G ...

2008

Finding Hamiltonian circuits in quasi-adjoint graphs

Dominique de Werra, Benjamin Leroy-Beaulieu

This paper is motivated by a method used for DNA sequencing by hybridization presented in [Jacek Blazewicz, Marta Kasprzak, Computational complexity of isothernnic DNA sequencing by hybridization, Discrete Appl. Math. 154 (5) (2006) 718-7291. This paper pr ...

2008

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The forthcoming arrival on the market of numerous protein therapeutics that require high clinical doses will foster the need for high-producing mammalian cell lines. Furthermore, pressures to reduce the development time for new therapeutics has meant more ...

EPFL2008

Experimental comparison between conventional and hybrid long-range surface plasmon waveguide bends

Olivier Martin, Claudio Dellagiacoma

We report on the characterization of long-range surface plasmon waveguide bends at telecom wavelengths (lambda=1550 nm). The structures consist of a thin Au stripe embedded in a transparent polymer film. When the polymer thickness is larger than the latera ...

2008

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Sandro Carrara, Carlotta Guiducci

This paper presents a microfabricated DNA chip for fully electronic, label-free DNA recognition, based on capacitance measurements. The chip has been fabricated in 0.5-mu m CMOS technology and it features an array of individually addressable sensing sites ...

2007

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