Publications related to Marfan syndrome

The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

Nikolaos Stergiopoulos, Georgios Rovas, Bram Trachet, Vasiliki Bikia, Stamatia Zoi Pagoulatou, Mauro Ferraro

The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the ...

2020

Notch1 haploinsufficiency causes ascending aortic aneurysms in mice

Freddy Radtke

An ascending aortic aneurysm (AscAA) is a life-threatening disease whose molecular basis is poorly understood. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV), which is associated with AscAA. Here, we describe a potentially novel role f ...

Amer Soc Clinical Investigation Inc2017

A patient-specific aortic valve model based on moving resistive immersed implicit surfaces

Alfio Quarteroni, Elena Faggiano, Marco Fedele

In this paper, we propose a full computational framework to simulate the hemodynamics in the aorta including the valve. Closed and open valve surfaces, as well as the lumen aorta, are reconstructed directly from medical images using new ad hoc algorithms, ...

Springer Heidelberg2017

Computational comparison of aortic root stresses in presence of stentless and stented aortic valve bio-prostheses

Alfio Quarteroni, Christian Vergara, Elena Faggiano

We provide a computational comparison of the performance of stentless and stented aortic prostheses, in terms of aortic root displacements and internal stresses. To this aim, we consider three real patients; for each of them, we draw the two prostheses con ...

Taylor & Francis Ltd2017

Cardiovascular morphometry with high-resolution 3D magnetic resonance: First application to left ventricle diastolic dysfunction

Nikolaos Stergiopoulos, Orestis Vardoulis, Davide Piccini

In this study, an image-based morphometry toolset quantifying geometric descriptors of the left ventricle, aorta and their coupling is applied to investigate whether morphological information can differentiate between subjects affected by diastolic dysfunc ...

Elsevier2017

Role of ERK1/2 activation and nNOS uncoupling on endothelial dysfunction induced by lysophosphatidylcholine

Nikolaos Stergiopoulos, Luciano Dos Santos Aggum Capettini

Background and aims: Lysophosphatidylcholine (LPC) - a main component of oxidized LDL -is involved in endothelial dysfunction that precedes atherosclerosis, with an increased superoxide anions and a reduced NO production via endothelial NO synthase (eNOS) ...

Elsevier2017

MATHICSE Technical Report : A patient-specific aortic valve model based on moving resistive immersed implicit surfaces

Alfio Quarteroni, Luca Dede', Elena Faggiano, Marco Fedele

In this paper, we propose a full computational pipeline to simulate the hemodynamics in the aorta including the valve. Closed and open valve surfaces, as well as the lumen aorta, are reconstructed directly from medical images using new ad hoc algorithms, a ...

MATHICSE2016

Multi-segment analysis of spinal kinematics during sit-to-stand in patients with chronic low back pain

Julien Favre, Thomas Legrand, Guillaume Christe

While alterations in spinal kinematics have been frequently reported in patients with chronic low back pain (CLBP), a better characterization of the kinematics during functional activities is needed to improve our understanding and therapeutic solutions fo ...

Elsevier Sci Ltd2016

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Marfan syndrome

The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

Viaduc du Crêt-de-l’Anneau : Vérification d’une structure existante au moyen du monitoring

Notch1 haploinsufficiency causes ascending aortic aneurysms in mice

A patient-specific aortic valve model based on moving resistive immersed implicit surfaces

Computational comparison of aortic root stresses in presence of stentless and stented aortic valve bio-prostheses

Cardiovascular morphometry with high-resolution 3D magnetic resonance: First application to left ventricle diastolic dysfunction

Role of ERK1/2 activation and nNOS uncoupling on endothelial dysfunction induced by lysophosphatidylcholine

OVERCORRECTED GLENOID IMPLANTS TO AVOID RECURRENT SUBLUXATION AFTER TOTAL SHOULDER ARTHROPLASTY: A PATIENT-SPECIFIC FINITE ELEMENT ANALYSIS

MATHICSE Technical Report : A patient-specific aortic valve model based on moving resistive immersed implicit surfaces

Multi-segment analysis of spinal kinematics during sit-to-stand in patients with chronic low back pain

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OVERCORRECTED GLENOID IMPLANTS TO AVOID RECURRENT SUBLUXATION AFTER TOTAL SHOULDER ARTHROPLASTY: A PATIENT-SPECIFIC FINITE ELEMENT ANALYSIS

Viaduc du Crêt-de-l’Anneau : Vérification d’une structure existante au moyen du monitoring

Notch1 haploinsufficiency causes ascending aortic aneurysms in mice

Role of ERK1/2 activation and nNOS uncoupling on endothelial dysfunction induced by lysophosphatidylcholine

The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

A patient-specific aortic valve model based on moving resistive immersed implicit surfaces

Computational comparison of aortic root stresses in presence of stentless and stented aortic valve bio-prostheses

Cardiovascular morphometry with high-resolution 3D magnetic resonance: First application to left ventricle diastolic dysfunction

MATHICSE Technical Report : A patient-specific aortic valve model based on moving resistive immersed implicit surfaces

Multi-segment analysis of spinal kinematics during sit-to-stand in patients with chronic low back pain