Concept
Grignard reaction
Related publications (86)
Rate-Determining Step for Electrochemical Reduction of Carbon Dioxide into Carbon Monoxide at Silver Electrodes
Sophia Haussener, Etienne Boutin
Silver is one of the most studied electrode materials for the electrochemical reduction of carbon dioxide into carbon monoxide, a product with many industrial applications. There is a growing number of reports in which silver is implemented in gas diffusio ...
2024Recent progress in alkynylation with hypervalent iodine reagents
Jérôme Waser, Eliott Hugo Joran Le Du
Although alkynes are one of the smallest functional groups, they are among the most versatile building blocks for organic chemistry, with applications ranging from biochemistry to material sciences. Alkynylation reactions have traditionally relied on the u ...
ROYAL SOC CHEMISTRY2023Nanomole-scale photochemical thiol-ene chemistry for high-throughput late-stage diversification of peptide macrocycles
Alexander Lund Nielsen, Mischa Schüttel, Mark Daniel Nolan
The photochemical thiol-ene reaction is an efficient method for rapid and chemoselective formation of thioether linkages under mild conditions. It has found widespread use in small-molecule synthesis as well as peptide and protein chemistry. While high-thr ...
WILEY2023Radical Alkynylations with EthynylBenziodoXolones: From Photocatalysis to Direct Excitation
Jérôme Waser, Stephanie Grace Elizabeth Amos
Ethynylbenziodoxolones (EBXs) have recently emerged as potent reagents for the alkynylation of radicals. Their combination with photocatalysis allows the synthesis of valuable alkynes at room temperature. Herein, we discuss two photomediated strategies for ...
SWISS CHEMICAL SOC2022Copper-Catalyzed Alkynylation of Hydrazides: An Easy Access to Functionalized Azadipeptides
Jérôme Waser, Eliott Hugo Joran Le Du, Julien Aymeric Borrel
We report a copper-catalyzed alkynylation of azadipeptides using ethynylbenziodoxolone (EBX) reagents. Nonsymmetrical ynehydrazides could be obtained in 25–97% yield using azaglycine derivatives as nucleophiles. The transformation is compatible with most f ...
2022Tosyloxybenziodoxolone: A Platform for Performing the Umpolung of Alkynes in One-Pot Transformations
Jérôme Waser, Julien Aymeric Borrel
Ethynylbenziodoxolones (EBXs) are commonly encountered reagents for the electrophilic alkynylation of nucleophiles. Herein, we report a one-pot, two-step process for EBX generation and their direct application in substrate functionalization. Our approach e ...
AMER CHEMICAL SOC2021Direct Photoexcitation of Ethynylbenziodoxolones: An Alternative to Photocatalysis for Alkynylation Reactions**
Jérôme Waser, Diana Cavalli, Franck Le Vaillant, Stephanie Grace Elizabeth Amos
Ethynylbenziodoxolones (EBXs) are commonly used as radical traps in photocatalytic alkynylations. Herein, we report that aryl-substituted EBX reagents can be directly activated by visible light irradiation. They act as both oxidants and radical traps, alle ...
WILEY-V C H VERLAG GMBH2021Operando XANES from first-principles and its application to iridium oxide
Nicola Marzari, Francesco Nattino
Efficient electro-catalytic water-splitting technologies require suitable catalysts for the oxygen evolution reaction (OER). The development of novel catalysts could benefit from the achievement of a complete understanding of the reaction mechanism on irid ...
ROYAL SOC CHEMISTRY2020Photocatalytic Umpolung of N- and O-substituted alkenes for the synthesis of 1,2-amino alcohols and diols
Jérôme Waser, Stefano Nicolai, Stephanie Grace Elizabeth Amos
We report an organophotocatalytic 1,2-oxyalkynylation of ene-carbamates and enol ethers using Ethynyl BenziodoXolones (EBXs). 1-Alkynyl-1,2-amino alcohols and diols were obtained in up to 89% yield. Photocatalytic formation of radical cations led to Umpolu ...
ROYAL SOC CHEMISTRY2020