Concept
Biomarker
Related publications (64)
A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model
Kristina Schoonjans, Vera Monica Lemos Da Silva, Evan Graehl Williams, Pan Xu, Amir Banaei Esfahani, Chen Li, Ruedi Aebersold
To-date, most proteomic studies aimed at discovering tissue-based cancer biomarkers have compared the quantity of selected proteins between case and control groups. However, proteins generally function in association with other proteins to form modules loc ...
2019Microfluidic-based immunohistochemistry for breast cancer diagnosis: a comparative clinical study
Martinus Gijs, Diego Gabriel Dupouy, Saska Brajkovic, Fabio Aimi
Breast cancer is a highly heterogeneous disease. The efficacy of tailored therapeutic strategies relies on the precise detection of diagnostic biomarkers by immunohistochemistry (IHC). Therefore, considering the increasing incidence of breast cancer cases, ...
2019Stroke and Amyloid-beta Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response
Neuroinflammation is involved in the pathogenesis of Alzheimer's disease, and the transcription factor NF-kappa B is a player in this event. We found here that the ischemic damage alone or in association with A beta(1-42) activates the NF-kappa B pathway, ...
2019Microfluidics as an Enabling Technology for Personalized Cancer Therapy
Tailoring patient‐specific treatments for cancer is necessary in order to achieve optimal results but requires new diagnostic approaches at affordable prices. Microfluidics has immense potential to provide solutions for this, as it enables the processing o ...
2019Aerolysin, a Powerful Protein Sensor for Fundamental Studies and Development of Upcoming Applications
Françoise Gisou van der Goot Grunberg
The nanopore electrical approach is a breakthrough in single molecular level detection of particles as small as ions, and complex as biomolecules. This technique can be used for molecule analysis and characterization as well as for the understanding of con ...
AMER CHEMICAL SOC2019Inhibitor-conjugated harmonic nanoparticles targeting fibroblast activation protein
Sandrine Gerber, Jérémy Vuilleumier, Raphaël Jovita De Matos
The recent progress in the engineering of nanosized inorganic materials presenting tailored physical properties and reactive surface for post-functionalization has opened promising avenues for the use of nanoparticles (NPs) in diagnosis and therapeutic int ...
2019Virus lasers for biological detection
The selective amplification of DNA in the polymerase chain reaction is used to exponentially increase the signal in molecular diagnostics for nucleic acids, but there are no analogous techniques for signal enhancement in clinical tests for proteins or cell ...
Springer2019Nanoparticle-Enhanced Plasmonic Biosensor for Digital Biomarker Detection in a Microarray
Hatice Altug, Filiz Yesilköy, Alexander Belushkin
Nanoplasmonic devices have become a paradigm for biomolecular detection enabled by enhanced light–matter interactions in the fields from biological and pharmaceutical research to medical diagnostics and global health. In this work, we present a bright-fiel ...
2018Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitul ...
2018Enhanced Sensing of Interleukin 8 by Stripping Voltammetry: Carbon Nanotubes versus Fullerene
The ability to detect protein biomarkers at a subnanomolar level represents a pervasive challenge in order to bring a significant improvement in early diagnosis or progression of pato-physiological processes. To this aim, Screen Printed Electrochemical Sen ...
SPRINGER-VERLAG SINGAPORE PTE LTD2018