Publications related to Intracellular transport

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

Luc Reymond, Fabien Kuttler, Milena Maria Schuhmacher, Manon Sandra Bardyn, Daria Korotkova, Triana Amen

Peroxisomes are eukaryotic organelles that are essential for multiple metabolic pathways, including fatty acid oxidation, degradation of amino acids, and biosynthesis of ether lipids. Consequently, peroxisome dysfunction leads to pediatric-onset neurodegen ...

2024

Membrane specificity of the human cholesterol transfer protein STARD4

Charlotte Julie Caroline Gehin

STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...

Academic Press Ltd- Elsevier Science Ltd2024

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

Juan Cruz Landoni Martin

Cristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms in the mitochondrion, a membrane-anchored long form (l-Op ...

Springernature2024

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui

G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13. However, our understanding of the G protein selectivity of GPCRs is incomplet ...

Cambridge2023

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

Martinus Gijs, Raphaël Etienne Jean Trouillon, Martin Rainer Wohlwend

Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-based ...

eLIFE SCIENCES PUBL LTD2023

A general strategy to develop fluorogenic polymethine dyes for bioimaging

Pablo Rivera Fuentes, Annabell Martin

Fluorescence imaging is an invaluable tool to study biological processes and further progress depends on the development of advanced fluorogenic probes that reach intracellular targets and label them with high specificity. Excellent fluorogenic rhodamine d ...

Berlin2023

Modulation of Subcellular Redox Homeostasis with Trialkylphosphines

Jade Noémie Nam Nguyen

Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced (GSH) and oxidized (GSSG) glutathione. In eukaryotic cells, this ratio ...

SWISS CHEMICAL SOC2022

Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

Pierre Gönczy, Georgios Hatzopoulos

Centrioles are eukaryotic organelles that template the formation of cilia and flagella, as well as organize the microtubule network and the mitotic spindle in animal cells. Centrioles have proximal-distal polarity and a 9 fold radial symmetry imparted by a ...

CELL PRESS2022

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Intracellular transport

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

Membrane specificity of the human cholesterol transfer protein STARD4

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

Development of methods for the synthesis of large combinatorial libraries of macrocyclic compounds

Neuronal migration prevents spatial competition in retinal morphogenesis

A general strategy to develop fluorogenic polymethine dyes for bioimaging

Modulation of Subcellular Redox Homeostasis with Trialkylphosphines

Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

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In situ architecture of Opa1-dependent mitochondrial cristae remodeling

Development of methods for the synthesis of large combinatorial libraries of macrocyclic compounds

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

Neuronal migration prevents spatial competition in retinal morphogenesis

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

Membrane specificity of the human cholesterol transfer protein STARD4

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Modulation of Subcellular Redox Homeostasis with Trialkylphosphines

Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

A general strategy to develop fluorogenic polymethine dyes for bioimaging