Concept
Hepatotoxicity
Related publications (63)
Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1
Kristina Schoonjans, Petar Petrov
Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteristic of ...
Amsterdam2024Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP
Henning Paul-Julius Stahlberg, Dongchun Ni
BSEP (ABCB11) is an ATP-binding cassette transporter that is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. BSEP dysfunction, caused by mutations or induced by drugs, is frequently associated with severe cholestatic live ...
Berlin2023Longitudinal incremental propensity score interventions for limited resource settings
Mats Julius Stensrud, Aaron Leor Sarvet
Many real‐life treatments are of limited supply and cannot be provided to all individuals in the population. For example, patients on the liver transplant waiting list usually cannot be assigned a liver transplant immediately at the time they reach highest ...
2023Dissecting the role of the asparagine synthesis in acute liver injury
Amino acids are some of the main building stones of life used in a variety of biological processes, such as protein synthesis, energy metabolism or even as precursors for hormone synthesis. How-ever, some of them also participate and coordinate certain cel ...
EPFL2022Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression
The liver is the largest solid organ and the only one capable of using regenerative mechanisms to recover its mass fully. Although liver regeneration from acute injuries has been effective and extensively studied, chronic liver damage has adverse effects o ...
EPFL2022Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes
In vitro models of human liver functions are used across a diverse range of applications in preclinical drug development and disease modeling, with particular increasing interest in models that capture facets of liver inflammatory status. This study invest ...
WILEY-V C H VERLAG GMBH2022Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance
A simple predictive biomarker for fatty liver disease is required for individuals with insulin resistance. Here, we developed a supervised machine learning-based classifier for fatty liver disease using fecal 16S rDNA sequencing data. Based on the Kangbuk ...
NATURE PORTFOLIO2022Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
Cristina Ramona Cudalbu, Jocelin Grosse, Veronika Rackayová, Emmanuelle Ines Flatt
Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora ...
2021