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Inhibition of coagulation factor XII (FXII) activity represents an attractive approach for the treatment and prevention of thrombotic diseases. The few existing FXII inhibitors suffer from low selectivity. Using phage display combined to rational design, w ...
Creative strategies for identifying new antibiotics are essential to addressing the looming threat of a post-antibiotic era. We here report the use of a targeted peptide phage display screen as a means of generating novel antimicrobial lipopeptides. Specif ...
The short-term mechanical strength of platelet-reinforced polymer composites was modeled using classical two-dimensional stress-transfer analysis. The stress field in the platelet and at the platelet/matrix interface was described in the presence of a matr ...
The short-term mechanical strength of platelet-reinforced polymer composites was modeled using classical two-dimensional stress-transfer analysis. The stress field in the platelet and at the platelet/matrix interface was described in the presence of a matr ...
Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidi ...
The aim of this study was to analyze the arterial wall response to plaque-prone hemodynamic environments, known to occur mainly in areas of arterial trees such as bifurcations and branching points. In these areas, the vasculature is exposed to cyclically r ...
