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Macrocycles are an attractive class of molecules due to their good binding properties and yet rather small size that allows, in many cases, crossing membranes to reach intracellular targets. In comparison to classical small molecule drugs, macrocycles are ...
Motion forecasting is crucial in enabling autonomous vehicles to anticipate the future trajectories of surrounding agents. To do so, it requires solving mapping, detection, tracking, and then forecasting problems, in a multi-step pipeline. In this complex ...
Nowadays, usage-based acquisition models for e-books, as PDA and EBA, are quite spread and allow libraries to offer wider collections, without acquiring them. A PDA with Ebook Central was implemented in 2019 and a first EBA with Wiley in 2021. The EPFL Lib ...
Given the increasing ubiquity of online embedded devices, analyzing their firmware is important to security, privacy, and safety. The tight coupling between hardware and firmware and the diversity found in embedded systems makes it hard to perform dynamic ...
Bicyclic peptide ligands are promising molecules for the development of new therapeutics. They combine advantages from large protein therapeutics and small molecule drugs. Large combinatorial libraries of bicyclic peptides can be generated and screened by ...
The application of click chemistry to develop libraries of organometallic ruthenium-arene complexes with potential anticancer properties has been investigated. A series of ruthenium-imidazole-triazole complexes, with hydrophobic tails, were prepared from a ...
The invention relates to a system and method to optimize navigation and recommendation in a distributed network of media libraries. According to the invention, it is proposed a system and a method to assist the selection of media items comprising the steps ...
Development of numerical methods for hydraulic fracture simulation has accelerated in the past two decades. Recent advances in hydraulic fracture modeling and simulation are driven by increased industry and research activity in oil and gas, a drive toward ...
We describe a tool that applies theorem proving technology to synthesize code fragments that use given library functions. Our approach takes into account polymorphic type constraints as well as code behavior. We have found our system to be useful for synth ...
Cyclic peptide disulfides (CXC) are an important class of biomolecules. The conjugation of cyclic peptide disulfides to synthetic polymers, however, is often difficult due to the presence of the disulfide bond combined with other potentially reactive side ...
