Concept
Benzodiazepine
Related publications (34)
Gamma Knife radiosurgery for intravestibular and intracochlear schwannomas
BackgroundSchwannomas of the VIIIth cranial nerve are benign tumours, with vast majority occurring in vestibular division. Rarely, they can also arise from distal branches of cochlear, superior or inferior vestibular. We review our experience with Gamma Kn ...
2019Biodegradable Wireless Microheaters for Transient Biomedical Implants
Jürgen Brugger, Giovanni Boero, Matthieu Jean Michel Rüegg, Remo Blum
Transient electronics show a great potential in the field of bioresorbable medical implants, for applications such as localized drug delivery for wound healing or following a surgical procedure. Once their function is fulfilled, such implants naturally deg ...
2019Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors
Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Jocelin Grosse, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Fiona Hollis, Michael van der Kooij, Ioannis Zalachoras, Laura Lozano Montes, Sonia Abad Florensa
Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...
Nature Publishing Group2018GABA A receptors in the ventral tegmental area control the outcome of a social competition in rats
Maria del Carmen Sandi Perez, Michael van der Kooij, Ioannis Zalachoras
Social dominance can be attained through social competitions. Recent work in both humans and rodents has identified trait anxiety as a crucial predictor of social competitiveness. In addition, the anxiolytic GABAA positive modulator, diazepam, injected eit ...
2018IoT Bio-Electronic Multi-Panel Device for On-line Monitoring of Anaesthesia Delivery
After a failure of "One-Size-Fits-All" approach on traditional treatment of diseases, the age of multi-faceted personalized medicine came into being for tailoring therapy to get the best response in the highest safety margin. Personalized drug dosage is on ...
EPFL2018Alterations in brain microstructure in rats that develop abnormal aggression following peripubertal stress
Maria del Carmen Sandi Perez, Sophie Elizabeth Walker
Exposure to early adversity is implicated in the development of aggressive behaviour later in life in some but not all individuals. The reasons for the variability in response to such experiences are not clear but may relate to pre‐existing individual diff ...
2018A novel electrochemical sensor for non-invasive monitoring of lithium levels in mood disorders
Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Criscuolo
Lithium is the main drug for the treatment of mood disorders. Due to its narrow therapeutic window, Therapeutic Drug Monitoring (TDM) is a norm during therapy in order to avoid adverse effects. Consequently, patients are obliged to frequent check-ups in ho ...
2018Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock
Felix Naef, Frédéric Bruno Martin Gachon, Jake Yeung
Mammalian physiology resonates with the daily changes in the external environment, allowing processes such as rest-activity cycles, metabolism, and body temperature to synchronize with daily changes in the surroundings. Studies have identified the molecula ...
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2018NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans
During active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists. BALB/c mice, predominantly used in TB drug development, do not reproduce this complex pathology thereby inaccurately predicting clinical outcome. We fou ...
Nature Publishing Group2017Allosteric cross-talk in chromatin can mediate drug-drug synergy
Paul Joseph Dyson, Ursula Röthlisberger, Tina Riedel, Giulia Palermo
Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated ...
2017