Concept

Body mass index

Related publications (81)

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that causes death of motor neurons. ALS patients and mouse models of familial ALS display organismal level metabolic dysfunction, which includes increased energy expenditure despite ...

Oxford University Press2014

Vitamin D and energy homeostasis-of mice and men

Johan Auwerx, Kristina Schoonjans, Alessia Perino

The vitamin D endocrine system has many extraskeletal targets, including adipose tissue. 1,25-Dihydroxyvitamin D-3, the active form of vitamin D, not only increases adipogenesis and the expression of typical adipocyte genes but also decreases the expressio ...

Nature Publishing Group2014

Asynchronous detection of error potentials

Inaki Asier Iturrate Gil

Recent developments in brain-machine interfaces (BMIs) have proposed the use of errorrelated potentials as cognitive signal that can provide feedback to control devices or to teach them how to solve a task. Due to the nature of these signals, all the propo ...

2014

Effects of Age, Sex and Treatment on Weight Loss Dynamics in Overweight People

David Atienza Alonso, Emiliano Luis Rincon Vallejos

The objective of this work is the evaluation of how sex, age and the kind of followed treatment affect weight loss, as well as the development of an explanation to assess the evolution of weight loss dynamics in overweight men and women. The methods use in ...

Canadian Science Publishing, Nrc Research Press2013

Influence of CRTC1 Polymorphisms on Body Mass Index and Fat Mass in Psychiatric Patients and the General Adult Population

Pierre Magistretti, Murielle Bochud, Jean-René Cardinaux

IMPORTANCE There is a high prevalence of obesity in psychiatric patients, possibly leading to metabolic complications and reducing life expectancy. The CREB-regulated transcription coactivator 1 (CRTC1) gene is involved in energy balance and obesity in ani ...

Amer Medical Assoc2013

Fused 3-Hydroxy-3-trifluoromethylpyrazoles Inhibit Mutant Huntingtin Toxicity

Ozgün Gökce, Davide Franceschini

Here, we describe the selection and optimization of a chemical series active in both a full-length and a fragment-based Huntington's disease (HD) assay. Twenty-four thousand small molecules were screened in a phenotypic HD assay, identifying a series of co ...

Amer Chemical Soc2013

Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice

Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin

The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Genetically modified C57BL/6J mice were produced by targeted disruption of the mct1 gene in order to understand the ...

Public Library of Science2013

Development and application of experimental tools to elucidate the gene regulatory network underlying adipogenesis

Carine Delattre-Gubelmann

Excess fat mass in obese individuals, which is characterized by an increase of white adipocyte cell size and number, significantly raises the risk of developing metabolic syndrome symptoms as well as cancer. A detailed understanding of the transcriptional ...

EPFL2013

Multidirectional transparent support for overground gait training

Joachim von Zitzewitz

Gait and balance training is an essential ingredient for locomotor rehabilitation of patients with neurological impairments. Robotic overhead support systems may help these patients train, for example by relieving them of part of their body weight. However ...

IEEE2013

A guide to analysis of mouse energy metabolism

Johan Auwerx

We present a consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models, including a practical guide to the assessment of energy expenditure, energy intake and body composition and statistic ...

2012

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