Concept

Spinal cord stimulator

Related publications (147)

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Quentin Barraud, Tomislav Milekovic, Marco Capogrosso, Fabien Bertrand Paul Wagner, Jérôme Gandar, Jean-Baptiste Mignardot, David Allenson Borton, Simone Ellen Joze Duis, Elodie Rey

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

Neural probe combining microelectrodes and a droplet-based microdialysis collection system for high temporal resolution sampling

Philippe Renaud, Arnaud Bertsch

We propose a novel neural probe which combines microfluidic channels with recording and stimulation electrodes. The developed microfabrication approach enables the concentration of every active element such as electrodes and the sampling inlet in close pro ...

Royal Society of Chemistry2016

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Quentin Barraud, Léonie Asboth, Marco Capogrosso, Pavel Musienko, Rubia van den Brand, Ivan Rusev Minev, Nikolaus Wenger, Jérôme Gandar, Arthur Edouard Hirsch, Laetitia Danielle Philippine Baud, Natalia Pavlova, Simone Ellen Joze Duis, Julie Kreider, Andrea Mortera

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

Apparatus and method for restoring voluntary control of locomotion in neuromotor impairments

Silvestro Micera, Grégoire Courtine, Joachim von Zitzewitz

It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is cap ...

2016

Peri-implant bone adaptations to overloading in rat tibiae: experimental investigations and numerical predictions

John Botsis, Joël Cugnoni, Marco Piccinini

Objectives(i) To assess the effects of mechanical overloading on implant integration in rat tibiae, and (ii) to numerically predict peri-implant bone adaptation. Materials and methodsTranscutaneous titanium implants were simultaneously placed into both tib ...

Wiley-Blackwell2016

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Eduardo Martin Moraud, Quentin Barraud, Léonie Asboth, Tomislav Milekovic, Marco Capogrosso, Pavel Musienko, Nicolas Vachicouras, Ivan Rusev Minev, Nikolaus Wenger, Jérôme Gandar, Arthur Edouard Hirsch, Natalia Pavlova, Simone Ellen Joze Duis

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

Muscle synergies and spinal maps are sensitive to the asymmetry induced by a unilateral stroke

Silvestro Micera, Martina Coscia

Background: Previous studies have shown that a cerebrovascular accident disrupts the coordinated control of leg muscles during locomotion inducing asymmetric gait patterns. However, the ability of muscle synergies and spinal maps to reflect the redistribut ...

Biomed Central Ltd2015

Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury

Grégoire Courtine

Recent preclinical advances highlight the therapeutic potential of treatments aimed at boosting regeneration and plasticity of spinal circuitry damaged by spinal cord injury (SCI). With several promising candidates being considered for translation into cli ...

Elsevier Science Bv2015

Size and Viewpoint of an Embodied Virtual Body Affect the Processing of Painful Stimuli

Olaf Blanke, Joan Llobera Mahy

Looking at one's own body might induce visual analgesia. However, the cognitive and physiological mechanisms underlying such visual analgesia are unknown. Because body and pain representations in the brain are multisensory, and have been reported to partia ...

Churchill Livingstone2015

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

José del Rocio Millán Ruiz, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Eduardo Martin Moraud, Pavel Musienko, Ivan Rusev Minev, Nikolaus Wenger, Marco Bonizzato, Janine Beauparlant, David Allenson Borton

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

Elsevier2014

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