Publications related to Myosin

AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn(2B/-) spinal muscular atrophy mice

Structural, functional and molecular cardiac defects have been reported in spinal muscular atrophy (SMA) patients and mouse models. Previous quantitative proteomics analyses demonstrated widespread molecular defects in the severe Taiwanese SMA mouse model. ...

OXFORD UNIV PRESS2023

In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4

Christian Heinis, Jonas Alfred Karl Wilbs, Davide Bertoldo, Ganesh Kumar Mothukuri, Raphael Johannes Gübeli

Actin is the most abundant protein in eukaryotic cells and is key to many cellular functions. The filamentous form of actin (F-actin) can be studied with help of natural products that specifically recognize it, as for example fluorophore-labeled probes of ...

2021

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

Alfio Quarteroni, Francesco Regazzoni

Cardiac in silico numerical simulations are based on mathematical models describing the physical processes involved in the heart function. In this review paper, we critically survey biophysically-detailed mathematical models describing the subcellular mech ...

SPRINGER SINGAPORE PTE LTD2020

A model for cellular mechanotransduction and contractility at finite strain

William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas

In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...

2018

A model for cellular mechanotransduction and contractility at finite strain

William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas

In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...

2018

Morphogenetic degeneracies in the actomyosin cortex

Sundar Ram Naganathan

One of the great challenges in biology is to understand the mechanisms by which morphogenetic processes arise from molecular activities. We investigated this problem in the context of actomyosin-based cortical flow in C. elegans zygotes, where large-scale ...

ELIFE SCIENCES PUBLICATIONS LTD2018

Microsurgery-aided in-situ force probing reveals extensibility and viscoelastic properties of individual stress fibers

Jean-Jacques Meister, Chiara Gabella, Benoît Vianay, Céline Jeanne Labouesse

Actin-myosin filament bundles (stress fibers) are critical for tension generation and cell shape, but their mechanical properties are difficult to access. Here we propose a novel approach to probe individual peripheral stress fibers in living cells through ...

Nature Publishing Group2016

A Robust Actin Filaments Image Analysis Framework

Giovanni Dietler, Sandor Kasas

The cytoskeleton is a highly dynamical protein network that plays a central role in numerous cellular physiological processes, and is traditionally divided into three components according to its chemical composition, i.e. actin, tubulin and intermediate fi ...

Public Library of Science2016

Screening of structurally diverse bicyclic peptide libraries by phage display

Davide Bertoldo

Bicyclic peptides are an attractive molecule format for the development of therapeutics and research tools. Our laboratory is specialized on the development of bicyclic peptide ligands by phage display. In brief, libraries of randompeptides each containing ...

EPFL2016

Cell Shape Dynamics Reveal Balance of Elasticity and Contractility in Peripheral Arcs

Jean-Jacques Meister, Chiara Gabella, Benoît Vianay, Céline Jeanne Labouesse

The mechanical interaction between adherent cells and their substrate relies on the formation of adhesion sites and on the stabilization of contractile acto-myosin bundles, or stress fibers. The shape of the cell and the orientation of these fibers can be ...

Cell Press2015

Myosin

AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn(2B/-) spinal muscular atrophy mice

In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

A model for cellular mechanotransduction and contractility at finite strain

A model for cellular mechanotransduction and contractility at finite strain

Morphogenetic degeneracies in the actomyosin cortex

Microsurgery-aided in-situ force probing reveals extensibility and viscoelastic properties of individual stress fibers

A Robust Actin Filaments Image Analysis Framework

Screening of structurally diverse bicyclic peptide libraries by phage display

Cell Shape Dynamics Reveal Balance of Elasticity and Contractility in Peripheral Arcs

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In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4

AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn(2B/-) spinal muscular atrophy mice

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

Cell Shape Dynamics Reveal Balance of Elasticity and Contractility in Peripheral Arcs

A model for cellular mechanotransduction and contractility at finite strain

Morphogenetic degeneracies in the actomyosin cortex

A model for cellular mechanotransduction and contractility at finite strain

Screening of structurally diverse bicyclic peptide libraries by phage display

Microsurgery-aided in-situ force probing reveals extensibility and viscoelastic properties of individual stress fibers

A Robust Actin Filaments Image Analysis Framework