Concept
Human genetic variation
Related publications (265)
Gene expression across mammalian organ development
Maria del Carmen Sandi Perez, Ioannis Xenarios
The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early or ...
2019Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes
Jacques Fellay, Nimisha Chaturvedi
Genetic polymorphism in the interferon lambda (IFN-lambda) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to interferon-based treatment. Here, we evaluate associations between IFN-l polymorphism and HCV va ...
ELIFE SCIENCES PUBLICATIONS LTD2019X-Ray Nanotomography of Individual Pulp Fibre Bonds Reveals the Effect of Wall Thickness on Contact Area
Fibre bonds play an essential role in various properties of paper. Much research has focused on their strength, but the determination of the actual contact area also provides a challenge. Many of the research methods rely on optical tools, which are restri ...
2019Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
Didier Trono, Priscilla Turelli, Evaristo Jose Planet Letschert, Julien Léonard Duc, Sandra Eloise Kjeldsen, Alexandre Coudray, Julien Paul André Pontis, Julien Duc
Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling coordinated genome-wide activation of species- and context-specific gene expre ...
2019