Concept
Immunoglobulin therapy
Related publications (33)
Cross-anatomical single-cell definition and characterization of human adipose progenitor niche
Adipose tissue is a key metabolic and highly-dynamic organ whose dysregulation may cause clinical conditions of concern such as obesity and lipodystrophy. Its function varies based on the anatomy, in fact, visceral adipose tissue expansion carries a greate ...
EPFL2023Clathrin-associated AP-1 control stermination of STING signalling
Andrea Ablasser, Jonathan Jean-Pierre Ricci, Chong Liu, Pengbiao Xu, Ying Liu, Sophie Marie Elisabeth Rivara
Stimulator of interferon genes (STING) functions downstream of cyclic GMP-AMP synthase in DNA sensing or as a direct receptor for bacterial cyclic dinucleotides and small molecules to activate immunity during infection, cancer and immunotherapy(1-10). Prec ...
NATURE PORTFOLIO2022The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity
Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...
EPFL2022DNA-based biomaterials for nanoscale controlled modulation of immune cells
Recent advances in the field of nanomaterials demonstrated how their use for vaccination can drastically improve immune responses, mainly by enhancing delivery and uptake of vaccine components. However, our understanding of the connections between presenta ...
EPFL2022A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma
Didier Trono, Priscilla Turelli, Florence Pojer, Charlène Mireille Raymonde Raclot, Valeria Cagno, Jérémy Campos, Céline Pellaton
The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies in the serum of an individual indicates previous infection or vaccination. However, it provides limited insight into the protective nature of this immune resp ...
AMER ASSOC ADVANCEMENT SCIENCE2021Human genomics of the humoral immune response against polyomaviruses
Jacques Fellay, Christian Axel Wandall Thorball, Zhi Ming Xu, Olivier Noël Marie Naret, Christian Hammer, Flavia Aurelia Shoko Hodel, Petar Scepanovic
Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta ...
OXFORD UNIV PRESS2021Studying the interactions between electro-magnetic elds and biological tissue
Drug delivery systems (DDS) were engineered to overcome the drawbacks of more common methods such as oral pills and intravenous injections. Implantable capsules that release anesthetic drugs locally for pain management after Total Knee Arthroplasty (TKA) a ...
2020Autologous Cell Therapy Approach for Duchenne Muscular Dystrophy using PiggyBac Transposons and Mesoangioblasts
Duchenne muscular dystrophy (DMD) is a lethal muscle-wasting disease currently without cure. We investigated the use of the PiggyBac transposon for full-length dystrophin expression in murine mesoangioblast (MABs) progenitor cells. DMD murine MABs were tra ...
CELL PRESS2018Encapsulation of Insulin-Secreting Cells Expressing a Genetically Encoded Fluorescent Calcium Indicator for Cell-Based Sensing In Vivo
Andreas Wiederkehr, Umberto De Marchi, Nicolas Bouche, Christophe Boss, Federico Sizzano, Mouna Conrad
The development of cell-based biosensors that give insight into cell and tissue function in vivo is an attractive technology for biomedical research. Here, the development of a cell line expressing a fluorescent calcium sensor for the study of beta-cell fu ...
Wiley2017Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade
Michele De Palma, Céline Wyser Rmili, Ece Kadioglu, Nicolo Rigamonti, Damya Laoui, Antonino Cassarà
Pathological angiogenesis is a hallmark of cancer and a therapeutic target. Vascular endothelial growth factor A (VEGFA) and angiopoietin-2 (ANGPT2; also known as ANG2) are proangiogenic cytokines that sustain tumor angiogenesis and limit antitumor immunit ...
American Association for the Advancement of Science2017