Concept
Trauma model of mental disorders
Related publications (4)
Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia
Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva
Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...
2024Peripubertal stress-induced heightened aggression: modulation of the glucocorticoid receptor in the central amygdala and normalization by mifepristone treatment
Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Stamatina Tzanoulinou, Orbicia Riccio Wicht, Vandana Veenit
Despite the enormous negative impact of excessive aggression for individuals and societies, there is a paucity of treatments. Here, using a peripubertal stress model of heightened aggression in rats, we investigated the involvement of the glucocorticoid sy ...
2019Low vagal tone in two rat models of psychopathology involving high or low corticosterone stress responses
Maria del Carmen Sandi Perez, Jocelin Grosse, Damien Sébastien Huzard, Sriparna Ghosal
The two stress-responsive physiological systems, autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis exert complementary and interrelated actions in the organism. Individuals that suffer stress-related psychopathologies frequently ...
2019CRHR1 links peripuberty stress with deficits in social and stress-coping behaviors
Maria del Carmen Sandi Perez, Orbicia Riccio Wicht, Vandana Veenit
Stressful life events during childhood and adolescence are important risk factors for the development of psychopathologies later in life. The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between earl ...
Pergamon-Elsevier Science Ltd2014