Concept

Ischemia

Related publications (76)

Identification and functional response of interstitial Cajal-like cells from rat mesenteric artery

Jean-Jacques Meister, Jean-Louis Bény, Lara Buscemi Estefanell, Aurélie Formey de Saint Louvent

Cells with irregular shapes, numerous long thin filaments, and morphological similarities to the gastrointestinal interstitial cells of Cajal (ICCs) have been observed in the wall of some blood vessels. These ICC-like cells (ICC-LCs) do not correspond to t ...

Springer-Verlag2011

Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction

Jeffrey Alan Hubbell

We present use of a synthetic, injectable matrix metalloproteinase (MMP)- responsive, bioactive hydrogel as an in situ forming scaffold to deliver thymosin beta 4 (T beta 4), a pro-angiogenic and pro-survival factor, along with vascular cells derived from ...

2011

Photodynamic therapy induces selective extravasation of macromolecules: Insights using intravital microscopy

Hubert van den Bergh, Elodie Debefve

Photodynamic therapy (PDT) with Visudyne acts by direct cellular phototoxicity and/or by an indirect vascular-mediated effect. Here, we demonstrate that the vessel integrity interruption by PDT can promote the extravasation of a macromolecular agent in nor ...

Elsevier2010

Application of the fastest route algorithm in the interactive simulation of the effect of local ischemia on the ECG

A method is described to determine the effect on the ECG of a reduced propagation velocity within an ischemic zone. The method was designed to change the activation sequence throughout the ventricles interactively, i.e. with a response time in the order of ...

2009

Cell-responsive hydrogel for encapsulation of vascular cells

Jeffrey Alan Hubbell

The in vitro potential of a synthetic matrix metalloproteinase (MMP)-responsive poly(ethylene glycol) (PEG)-based hydrogel as a bioactive co-encapsulation system for vascular cells and a small bioactive peptide, thymosin beta 4 (T beta 4), was examined. We ...

2009

Stem cell-based cardiovascular tissue engineering

Thomas Krähenbühl

Cardiovascular diseases, including myocardial infarction, are the leading cause of death worldwide for both men and women. Current therapies are limited by the restricted intrinsic regeneration capacity of the heart and by the lack of organs for transplant ...

EPFL2009

Combination Therapy Using Verteporfin and Ranibizumab; Optimizing the Timing in the CAM Model

Hubert van den Bergh, Elodie Debefve

Combining photodynamic therapy (PDT) using verteporfin (Visudyne(R)) with ranibizumab (Lucentis(R)) can optimize the overall treatment outcome by providing more efficacy in vessel closure, and thus reduce the need for retreatment in patients with wet age-r ...

2009

Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2

Purpose: Apoptosis is known to play a key role in cell death after retinal ischemia. However, little is known about the kinetics of the signaling pathways involved and their contribution to this process. The aim of this study was to determine whether chang ...

2009

Design and Optimization of a Lactate Amperometric Biosensor based on Lactate Oxidase and Multi Walled-Carbon Nanotubes

Giovanni De Micheli, Sandro Carrara, Cristina Boero

Lactate concentration in physiological fluids is an indicator of the energy production under anaerobic conditions of the whole organism [1]. Normal value for lactate level in blood ranges from 0.5 – 2.5 mM. Blood lactate values exceeding 7-8 mM are sometim ...

2008

The MRL mouse repairs both cryogenic and ischemic myocardial infarcts with scar

Yann Barrandon, Lukas Kappenberger, Hans-Anton Lehr

Objective: The MRL mouse strain shows extraordinary wound healing capacities. Some years ago, Leferovich et al. (Proc Natl Acad Sci U. S. A. 2001;98:9830-35) have reported the absence of scar formation after cryogenically-induced right ventricular myocardi ...

Elsevier2008

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