Publications related to Immunoglobulin E

A parallelized, automated platform enabling individual or sequential ChIP of histone marks and transcription factors

Bart Deplancke, Vincent Roland Julien Gardeux, Jia Yuan Jiang, Riccardo Dainese, Daniel Alpern, Antonio Carlos Alves Meireles Filho, Gerard Llimos Aubach

Despite its popularity, chromatin immunoprecipitation followed by sequencing (ChIP-seq) remains a tedious (>2 d), manually intensive, low-sensitivity and low-throughput approach. Here, we combine principles of microengineering, surface chemistry, and molec ...

NATL ACAD SCIENCES2020

Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

Li Tang, Lixia Wei, Yuqing Xie, Hacer Arik

Interleukin-2 (IL-2) is a potent T-cell mitogen that can adjuvant anti-cancer adoptive T-cell transfer (ACT) immunotherapy by promoting T-cell engraftment. However, the clinical applications of IL-2 in combination with ACT are greatly hindered by the sever ...

2019

Structure of the human multidrug transporter ABCG2

Henning Paul-Julius Stahlberg

ABCG2 is a constitutively expressed ATP-binding cassette (ABC) transporter that protects many tissues against xenobiotic molecules. Its activity affects the pharmacokinetics of commonly used drugs and limits the delivery of therapeutics into tumour cells, ...

Springer Nature2017

Exploiting Old Pathogens to Create New Therapeutics

Nicola Harris, Tiffany Babette Angélique Bouchery

Intestinal worms are well known for their potent immuno-modulatory capacity. In a recent study, Navarro et al. (2016) identify a secreted hookworm protein that can suppress allergic responses in both mice and humans. This represents an exciting strategy fo ...

Cell Press2016

Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection

Nicola Harris, Ilaria Mosconi, Lalit Kumar Dubey, Luc Xavier Marie Lebon

Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune responses and undergo a remarkable expansion in response to inflammatory stimuli. Although the formation of B cell follicles was previously thought to be restricted ...

Elsevier2016

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

Jeffrey Alan Hubbell, Melody Swartz, Benjamin John Marsland, Alexandre de Titta, Marie Ballester, Laura Jeanbart

An emerging strategy in preventing and treating airway allergy consists of modulating the immune response induced against allergens in the lungs. CpG oligodeoxynucleotides have been investigated in airway allergy studies, but even if promising, efficacy re ...

Nature Publishing Group2015

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Jacques Rougemont, Laure Menin, Nicola Harris, Alessandra Piersigilli, Benjamin John Marsland, Mario Michael Zaiss, Ilaria Mosconi, Lalit Kumar Dubey, Alexis Rapin, Luc Xavier Marie Lebon, Andrew J. Macpherson

Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or w ...

Elsevier2015

Fabrication of a high aspect ratio (HAR) micropillar filter for a magnetic bead-based immunoassay

Martinus Gijs, Christine Ruffert

A microfluidic chip has been realized for investigating immune cell (U937) activation with lipopolysaccharide (LPS) and subsequent pro-inflammatory cytokine (Interleukin-6, IL-6) detection (Ruffert et al. Proc. EMBL Conference Microfluidics 2012a, p 184; P ...

Springer2014

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Immunoglobulin E

A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies

Novel Analytical Methods for Allergy-Related Studies

A parallelized, automated platform enabling individual or sequential ChIP of histone marks and transcription factors

Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

Structure of the human multidrug transporter ABCG2

Exploiting Old Pathogens to Create New Therapeutics

Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Fabrication of a high aspect ratio (HAR) micropillar filter for a magnetic bead-based immunoassay

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Chat with Graph Search

A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies

Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

A parallelized, automated platform enabling individual or sequential ChIP of histone marks and transcription factors

Structure of the human multidrug transporter ABCG2

Exploiting Old Pathogens to Create New Therapeutics

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

Fabrication of a high aspect ratio (HAR) micropillar filter for a magnetic bead-based immunoassay