Concept

Neural fold

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Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for reconstructing and simulating neocortical microcircuitry. In one aspect, a method includes providing a model of neural tissue, the model including differ ...

2018

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Mutations in a number of genes cause familial forms of Parkinson's disease (PD), including mutations in the vacuolar protein sorting 35 ortholog (VPS35) and parkin genes. In this study, we identify a novel functional interaction between parkin and VPS35. W ...

OXFORD UNIV PRESS2018

Neuroprosthetic devices are engineered to study, support or replace impaired functions of the nervous system. The neural interface is an essential element of neuroprosthetic systems as it allows for transduction of signals and stimuli of desired functions ...

EPFL2018

Development and Characterization of PEDOT:PSS/Alginate Soft Microelectrodes for Application in Neuroprosthetics

Diego Ghezzi, Marc Olivier Heuschkel, Flavio Maurizio Mor, Marta Jole Ildelfonsa Airaghi Leccardi, Laura Ferlauto, Paola Vagni, Estelle Annick Cuttaz

Reducing the mechanical mismatch between the stiffness of a neural implant and the softness of the neural tissue is still an open challenge in neuroprosthetics. The emergence of conductive hydrogels in the last few years has considerably widened the spectr ...

2018

Théâtre Vidy Lausanne - A Double-Layered Timber Folded Plate Structure

Yves Weinand, Julien Gamerro, Christopher Werner Matthias Robeller

This article describes the first full-scale realization of a double-layered, folded plate structure (DLFP), for a new hall for the Théâtre Vidy Lausanne. (Fig. 1). Enabled by a novel double-tenon connection technology, the shape of the components simultane ...

2017

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Neuroprostheses based on electrical stimulation are becoming a therapeutic reality, dramatically improving the life of disabled people. They are based on neural interfaces that are designed to create an intimate contact with neural cells. These devices spe ...

Ieee-Inst Electrical Electronics Engineers Inc2017

Reconstructing Evolving Tree Structures in Time Lapse Sequences by Enforcing Time-Consistency

Pascal Fua, Engin Türetken, Raphael Sznitman, Agata Justyna Mosinska, Jan Kybic, Przemyslaw Rafal Glowacki, Miguel Amável Dos Santos Pinheiro, Daniel Lebrecht

We propose a novel approach to reconstructing curvilinear tree structures evolving over time, such as road networks in 2D aerial images or neural structures in 3D microscopy stacks acquired in vivo. To enforce temporal consistency, we simultaneously proces ...

2017

Materials and technologies for soft implantable neuroprostheses

Stéphanie Lacour, Grégoire Courtine

Implantable neuroprostheses are engineered systems designed to restore or substitute function for individuals with neurological deficits or disabilities. These systems involve at least one uni-or bidirectional interface between a living neural tissue and a ...

Nature Publishing Group2016

Methylglyoxal, the dark side of glycolysis

Pierre Magistretti, Igor Allaman

Glucose is the main energy substrate for the brain. There is now extensive evidence indicating that the metabolic profile of neural cells with regard to glucose utilization and glycolysis rate is not homogenous, with a marked propensity for glycolytic gluc ...

Frontiers Research Foundation2015

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation

Daniel Constam, Sylvain Frédéric Bessonnard

The first cell differentiation in mammalian embryos segregates polarized trophectoderm cells from an apolar inner cell mass (ICM). This lineage decision is specified in compacted morulae by cell polarization and adhesion acting on the Yes-associated protei ...

Rockefeller Univ Press2015