Publications related to Hearing loss

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro

Hearing Loss (HL) is the most prevalent sensorineural disorder, affecting 360 million people worldwide. As genetic causes lead to 50% of pre-lingual deafness, gene therapy is considered as a potential therapeutic strategy. Mutations in the TMC1 gene are li ...

MARY ANN LIEBERT, INC2019

Inner ear cellular imaging through scattering bone

Demetri Psaltis, Marilisa Romito

Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Imaging hair cells through laser-ablated cochlear bone

Demetri Psaltis, Ye Pu, Marilisa Romito

We report an innovative technique for the visualization of cells through an overlying scattering medium by combining femtosecond laser bone ablation and two-photon excitation fluorescence (TPEF) microscopy. We demonstrate the technique by imaging hair cell ...

OPTICAL SOC AMER2019

Numerical analysis for detecting head losses in trifurcations of high head in hydropower plants

François Avellan, Ramiro Gustavo Ramirez Camacho

Many different types of branching have been developed, such as bifurcation, trifurcation, and manifolds, among others. These configurations are used in penstocks to transport water from surge tanks to power houses in order to feed several turbines at the s ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Fingerprinting Big Data: The Case of KNN Graph Construction

Rachid Guerraoui, Anne-Marie Kermarrec, Olivier Ruas

We propose fingerprinting, a new technique that consists in constructing compact, fast-to-compute and privacy-preserving binary representations of datasets. We illustrate the effectiveness of our approach on the emblematic big data problem of K-Nearest-Nei ...

2019

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids

Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

The cochlea possesses a robust circadian clock machinery that regulates auditory function. How the cochlear clock is influenced by the circadian system remains unknown. Here, we show that cochlear rhythms are system driven and require local Bmal1 as well a ...

CELL PRESS2019

Auditory Brainstem Implants: Recent Progress and Future Perspectives

Stéphanie Lacour, Nicolas Vachicouras

The auditory brainstem implant (ABI) was first developed nearly 40 years ago and provides auditory rehabilitation to patients who are deaf and ineligible for cochlear implant surgery due to abnormalities of the cochlea and cochlear nerve. The aims of the f ...

2019

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro

Since most dominant human mutations are single nucleotide substitutions(1,2), we explored gene editing strategies to disrupt dominant mutations efficiently and selectively without affecting wild-type alleles. However, single nucleotide discrimination can b ...

NATURE PUBLISHING GROUP2019

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Hearing loss

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Inner ear cellular imaging through scattering bone

Imaging hair cells through laser-ablated cochlear bone

Numerical analysis for detecting head losses in trifurcations of high head in hydropower plants

Fingerprinting Big Data: The Case of KNN Graph Construction

Biomedical optical techniques for intracochlear cellular imaging

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids

ArASL: Arabic Alphabets Sign Language Dataset

Auditory Brainstem Implants: Recent Progress and Future Perspectives

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

Graph Chatbot

Chat with Graph Search

Numerical analysis for detecting head losses in trifurcations of high head in hydropower plants

Inner ear cellular imaging through scattering bone

Imaging hair cells through laser-ablated cochlear bone

Biomedical optical techniques for intracochlear cellular imaging

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Fingerprinting Big Data: The Case of KNN Graph Construction

ArASL: Arabic Alphabets Sign Language Dataset

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids

Auditory Brainstem Implants: Recent Progress and Future Perspectives