Concept

Aldol

Related publications (10)

Catalytic Upgrading of Biomass-Derived Carboxylic Acids to Fuels and Chemicals

Our reliance on fossil fuels, which is unsustainable due to dwindling reserves, has led to various environmental issues. Lignocellulosic biomass could serve as a renewable source of carbon and energy for the production of fuels and chemicals. While several ...

EPFL2019

Efficient Asymmetric Synthesis of Long-Chain Polyketides Containing up to Ten Contiguous Stereogenic Centres by Double Chain Elongation

Pierre Vogel, Rosario Scopelliti, Maris Turks

The 2,3-anti-3,4-syn-stereotriad (1Z,2S,3R,4S)-1-ethylidene-2,4-dimethyl-3-[(1S)-1-phenylethoxy]-5-oxopent-1-yl isobutyrate {(-)-8, obtained in a one-pot operation from the trimethylsilyl (Z)-enol ether derived from pentan-3-one and (1E,3Z)-1[(1S)-phenylet ...

2011

B-Alkylcatecholborane-Mediated Tandem Radical Conjugated Addition-Aldol Cyclization

Philippe Renaud, Kurt Schenk

A one-pot procedure involving radical conjugate addition of B-alkylcatecholboranes to enones followed by intramolecular aldol reaction is reported. Application to the stereoselective synthesis of monocyclic and bicyclic products with up to four contiguous ...

2009

Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

Aldol reaction of allomaltol with arom. aldehydes, e.g., RC6H4CHO, R = H, 4-NO2, 4-F, 2-F and 3,4,5-(MeO)3C5H2CHO, gave 2-(hydroxyphenylmethyl)-3-hydroxy-6-methylpyran-4(1)-ones, maltol-derived ligands. Organometallic Ru(II)-arene complexes, [RuCl2(cymene) ...

2009

Expeditious asymmetric synthesis of a stereoheptad corresponding to the C(19)-C(27)-ansa chain of rifamycins: Formal total synthesis of Rifamycin S

Pierre Vogel, Maris Turks, Xiaogen Huang

In the presence of sulfur dioxide and an acid promoter, (-)-(1E,3Z)-2-methyl-1-((1S)-1-phenyleth- oxy)penta-1,3-dien-3-yl isobutyrate reacts with (Z)-3-(trimethylsilyloxy)-pent-2-ene giving a silyl sulfinate intermediate that undergoes, in the presence of ...

2005

Information extraction from the Evolving Factor Analysis

Simon Crelier, Michael Amrhein

The goal of our project (HES-SO n°11246) is to develop chemometric methods that enhance the development of chemical reactions. Semi-batch experiments are performed using a fully automated chemical reactor. Real-time analytical data, infrared (IR) spectra f ...

2005

Chemometric optimization of chemical reactions with spectroscopic measurements

Michael Amrhein

This project aims at the optimization of chemical reactions by using online analytical and chemometric methods. The experiments are carried out in a fully automated chemical reactor (1 liter). The host computer controls the standard process variables such ...

2004

Synthesis of a C29-C51 Subunit of Spongistatin 1 (Altohyrtin A) Starting from (R)-3-Benzyloxy-2-methylpropan-1-ol

Pierre Vogel

A protected C29-C51 subunit ((+)-38) of Spongistatin 1 has been obtained. Key steps involve the aldol condensation of (3S,4R)-3-methyl-7-[(paramethoxybenzyl)oxy]-4-[(triethylsilyl)oxy]octan-2-one ((-)-6) with (tert-butyl)dimethylsilyl 4-deoxy-2,3-di-O-(met ...

2000

Asymmetric syntheses of new polyhydroxylated quinolizidines: Cross-aldol reactions of 7-oxabicyclo[2.2.1]heptan-2-one and 3a,4a,7a,7b-tetrahydro[1,3]dioxolo[4,5]furo[2,3-d]isoxazole-3-carbaldehy de derivatives

Pierre Vogel

The cross-aldolization of (-)-(1S,4R,5R,6R)-6-endo-chloro-5-exo-(phenylseleno)-7-oxabicyclo[2.2.1] heptan-2-one ((-)-25) and of(+)-(3aR,4aR,7aR,7bS)- ((+)-26) and(-)-(3aS,4aS,7aS,7bR)-3a,4a,7a,7b-tetrahydro-6,6-dimethyl[1,3]dioxolo [4,5]furo[2,3-d]isoxazol ...

2000

A novel aldol condensation alternative: a,b-unsaturated aldehydes from 3-hydroxy-1-alkynes via dihydrodioxepins

The controlled aldol condensation between an aliph. ketone and an acetaldehyde equiv. remains a challenge. One soln. to this evergreen problem consists of the nucleophilic addn. of acetylene to the ketone and the subsequent isomerization of the resulting 3 ...

1998

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.