Concept
Polymorphism (biology)
Related publications (103)
Hierarchical Protofilament Intertwining Rules the Formation of Mixed-Curvature Amyloid Polymorphs
Giovanni Dietler, Henning Paul-Julius Stahlberg, Meltem Tatli, Francesco Simone Ruggeri, Jiangtao Zhou, Salvatore Assenza, Raffaele Mezzenga
Amyloid polymorphism is a hallmark of almost all amyloid species, yet the mechanisms underlying the formation of amyloid polymorphs and their complex architectures remain elusive. Commonly, two main mesoscopic topologies are found in amyloid polymorphs cha ...
Wiley2024Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks
Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis con-founds our understanding of how mutations affect the expression patterns of gene regulatory networks, a chal-lenge exacerbated by the dependence of ...
AMER ASSOC ADVANCEMENT SCIENCE2023Wind Defiant Morphing Drones
Dario Floreano, Charalampos Vourtsis, Victor Casas Rochel, William John Stewart
Intense winds are a challenge for vertical take-off and landing drones with wings. In particular, in the hovering regime, wings are sensitive to wind currents that can be detrimental to their operational and energetic performances. Tail-sitters are particu ...
2023Capturing Types
Martin Odersky, Aleksander Slawomir Boruch-Gruszecki, Ondrej Lhoták
Type systems usually characterize the shape of values but not their free variables. However, many desirable safety properties could be guaranteed if one knew the free variables captured by values. We describe CC
New York2023Mechanism balancing taxonomy
Simon Nessim Henein, Florent Cosandier, Hubert Pierre-Marie Benoît Schneegans
The balancing of mechanisms consists in distributing their moving masses, inertias, and elastic components in order to achieve key mechanical properties, such as the elimination of the shaking forces and moments exported onto their supporting structure or ...
2023A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes
Kathryn Hess Bellwald, Lida Kanari, Martina Scolamiero
Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually involve user-selected morphometric features, which preclude the identification of a spectrum of context-dependent morphological phenot ...
NATURE PORTFOLIO2022Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations
Jacques Fellay, Zhi Ming Xu, Sina Rüeger
Genome-wide association studies rely on the statistical inference of untyped variants, called imputation, to increase the coverage of genotyping arrays. However, the results are often suboptimal in populations underrepresented in existing reference panels ...
San Francisco2022A single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae
Melanie Blokesch, Sandrine Stutzmann, Alexis Joseph Proutière, Loriane Bader, Milena Jadwiga Jaskolska
Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive behavior ...
2022Sharp turning maneuvers with avian-inspired wing and tail morphing
Dario Floreano, Valentin Wüest, Enrico Ajanic, Mir Alikhan Bin Mohammad Feroskhan
Flight in dense environments, such as forests and cities requires drones to perform sharp turns. Although fixed-wing drones are aerodynamically and energetically more efficient than multicopters, they require a comparatively larger area to turn and thus ar ...
2022A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913
Jacques Fellay, Christian Axel Wandall Thorball, Shuting Xu
Upon recognition of aberrantly located DNA, the innate immune sensor cyclic GMP-AMP synthase (cGAS) activates stimulator of IFN genes (STING)/IFN regulatory factor (IRF)3-driven antiviral responses. In this study, we characterized the ability of a specific ...
AMER ASSOC IMMUNOLOGISTS2022