Concept

Signal peptide

Related publications (161)

C-Terminal Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative Alkynylation

Jérôme Waser, Franck Le Vaillant, Marion Marie-Agnès Garreau

We report the first decarboxylative alkynylation of the C-terminus of peptides starting from free carboxylic acids. The reaction is fast, metal-free, and proceeds cleanly to afford alkynylated peptides with a broad tolerance for the C-terminal amino acid. ...

2019

Method for Identification of Threonine Isoforms in Peptides by Ultraviolet Photofragmentation of Cold Ions

Vladimir Kopysov, Aleksandr Pereverzev, Elizaveta Solovyeva

Identification of isomeric amino acid residues in peptides and proteins is challenging but often highly desired in proteomics. One of the practically important cases that require isomeric assignments is that associated with single-nucleotide polymorphism s ...

AMER CHEMICAL SOC2019

Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Jean-Claude Bünzli, Chen Xie

Acting as an extracellular matrix protein receptor, alpha(v)beta(3) integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific alpha(v)beta(3)-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-R-n) are demons ...

WILEY2019

Synthesis of DNA‐encoded disulfide‐ and thioether‐cyclized peptides

Christian Heinis, Van Manh Pham

DNA-encoded chemical library technologies enable the screening of large combinatorial libraries of chemically and structurally diverse molecules, including short cyclic peptides. A challenge in the combinatorial synthesis of cyclic peptides is the final st ...

2019

Differential presentation of a single antimicrobial peptide is sufficient to identify LPS from distinct bacterial samples

Timothy Matthias Reichart

Rapid detection and identification of bacteria is important for human health, biodefense, and food safety. Small arrays of different antimicrobial peptides (AMPs) enable the identification of lipopolysaccharide (LPS) samples from a variety of bacterial spe ...

2019

Compiling Permutations for Superconducting QPUs

Giovanni De Micheli, Mathias Soeken, Fereshte Mozafari Ghoraba, Bruno Schmitt Antunes

In this paper we consider the compilation of quantum state permutations into quantum gates for physical quantum computers. A sequence of generic single-target gates, which realize the input permutation, are extracted using a decomposition based reversible ...

IEEE2019

Peptide Bond Ultraviolet Absorption Enables Vibrational Cold-Ion Spectroscopy of Nonaromatic Peptides

Vladimir Kopysov, Aleksandr Pereverzev

Peptide-bond VUV absorption is inherent to all proteins and peptides. Although widely exploited in top-down proteomics for photodissociation, this absorption has never been spectroscopically characterized in the gas phase. We have measured VUV/UV photofrag ...

2018

Drugs Based on de novo-developed Peptides are Coming of Age

Christian Heinis

Naturally evolved peptides, such as the hormone oxytocin or the anti-bacterial vancomycin, have seen decades of success as powerful therapeutics due to many of the favorable properties of peptides. Not every desired target has a naturally occurring bioacti ...

SWISS CHEMICAL SOC2018

Polar Hinges as Functionalized Conformational Constraints in (Bi) cyclic Peptides

Christian Heinis, Sangram Shivdas Kale

Two polar hinges for cyclization of peptides have been developed, leading to bicyclic peptides and cyclized peptides with improved solubility and biological activity. Increasingly, we note that a good aqueous solubility of peptides is an absolute prerequis ...

Wiley-Blackwell2017

Development of an albumin-binding ligand for prolonging the plasma half-life of peptide therapeutics

Alessandro Zorzi

Peptides represent a promising format for the development of therapeutics since they combine the advantages of proteins and small molecules. Several techniques based on rational design or in vitro evolution can be used to develop peptides as therapeutics. ...

EPFL2017

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