Concept

Multiple sclerosis

Related publications (163)

The E protein-TCF1 axis controls gamma delta T cell development and effector fate

TCF1 plays a critical role in T lineage commitment and the development of alpha beta lineage T cells, but its role in gamma delta T cell development remains poorly understood. Here, we reveal a regulatory axis where T cell receptor (TCR) signaling controls ...

CELL PRESS2021

Detecting Compensatory Motions and Providing Informative Feedback During a Tangible Robot Assisted Game for Post-Stroke Rehabilitation

Pierre Dillenbourg, Friedhelm Christoph Hummel, Barbara Bruno, Maximilian Jonas Wessel, Ayberk Özgür, Hala Khodr

Gamified rehabilitation tackles the problem of keeping patients engaged in, and motivated to do physical rehabilitation to improve its efficacy. However, with respect to standard rehabilitation, patients are freer to move about and may compensate their mot ...

IEEE2021

IL-17 controls central nervous system autoimmunity through the intestinal microbiome

Sandrine Natacha Isaac

Interleukin-17A- (IL-17A) and IL-17F-producing CD4(+) T helper cells (T(H)17 cells) are implicated in the development of chronic inflammatory diseases, such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). T-H 17 ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Hierarchical Microstructure Informed Tractography

Gabriel Girard, Alessandro Daducci, Maxime Descoteaux

Background: Tractography uses diffusion magnetic resonance imaging to noninvasively infer the macroscopic pathways of white matter fibers and it is the only available technique to probe in vivo the structural connectivity of the brain. However, despite thi ...

MARY ANN LIEBERT, INC2021

A novel fatigue life prediction methodology based on energy dissipation in viscoelastic materials

Thomas Keller, Ghazaleh Eslami

This paper introduces a new fatigue life prediction methodology for viscoelastic materials in the tension-tension fatigue loading region. The model was established based on the total amount of energy dissipated during fatigue loading, and offers two main a ...

ELSEVIER SCI LTD2021

Prioritization of cell types responsive to biological perturbations in single-cell data with Augur

Grégoire Courtine, Jordan Squair, Matthieu Pierre Gautier, Michael Alexander Skinnider

Advances in single-cell genomics now enable large-scale comparisons of cell states across two or more experimental conditions. Numerous statistical tools are available to identify individual genes, proteins or chromatin regions that differ between conditio ...

NATURE RESEARCH2021

Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model This is the reply to a comment "Alpha-synuclein oligomerization and aggregation: A model will always be a model" on the original article "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get". The articles are accompanied by a Preface "How good are cellular models?".

Hilal Lashuel

Alpha-synuclein oligomerization is one of the early events on the pathway to Lewy body formation. Therefore, interfering with this process holds tremendous potential for developing therapies that block alpha-Syn pathology formation and toxicity. The develo ...

WILEY2021

High-resolution fast-tomography brain-imaging beamline at the Taiwan Photon Source

Giorgio Margaritondo

The new Brain Imaging Beamline (BIB) of the Taiwan Photon Source (TPS) has been commissioned and opened to users. The BIB and in particular its endstation are designed to take advantage of bright unmonochromatized synchrotron X-rays and target fast 3D imag ...

INT UNION CRYSTALLOGRAPHY2021

Evolution of Cortical and White Matter Lesion Load in Early-Stage Multiple Sclerosis: Correlation With Neuroaxonal Damage and Clinical Changes

Meritxell Bach Cuadra, Cristina Granziera, Guillaume Bonnier, Mario Joao Fartaria de Oliveira, Po-Jui Lu

Introduction:Changes in cortical and white matter lesion (CL, WML) load are pivotal metrics to diagnose and monitor multiple sclerosis patients. Yet, the relationship between (i) changes in CL/WML load and disease progression and between (ii) changes in CL ...

FRONTIERS MEDIA SA2020

Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity

Tobias Kober, Bénédicte Marie Maréchal, Mario Joao Fartaria de Oliveira

Neurofilament light chain (NfL) has been demonstrated to correlate with multiple sclerosis disease severity as well as treatment response. Nevertheless, additional serum biomarkers are still needed to better differentiate disease activity from disease prog ...

2020

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