Concept

Congenital adrenal hyperplasia

Related publications (13)

Neural Annotation Refinement: Development of a New 3D Dataset for Adrenal Gland Analysis

Pascal Fua, Jiancheng Yang, Pamuditha Udaranga Wickramasinghe, Rui Shi

The human annotations are imperfect, especially when produced by junior practitioners. Multi-expert consensus is usually regarded as golden standard, while this annotation protocol is too expensive to implement in many real-world projects. In this study, w ...

SPRINGER INTERNATIONAL PUBLISHING AG2022

Antibody-Coated Wearable Organic Electrochemical Transistors for Cortisol Detection in Human Sweat

Danick Briand, Marwan El Chazli, Silvia Demuru, Jaemin Kim

The dysregulation of the hormone cortisol is related to several pathological states, and its monitoring could help prevent severe stress, fatigue, and mental diseases. While wearable antibody-based biosensors could allow real-time and simple monitoring of ...

AMER CHEMICAL SOC2022

New approaches to uncover the minimally functional hematopoietic niche using the adipocytic differentiation axis: pharmacological modulation and adrenal niche induction

Frédérica Schyrr

Hematopoietic Stem and Progenitor Cells (HSPCs) reside in their niche, a structure that regulates the balance of cellular quiescence, self-renewal and commitment towards differentiated cells. This highly plastic niche is formed by several cellular players, ...

EPFL2022

Extended gate field-effect-transistor for sensing cortisol stress hormone

Mihai Adrian Ionescu, Junrui Zhang, Sadegh Kamaei Bahmaei, Hoël Maxime Guérin, Luca Capua, Shokoofeh Sheibani, Sayedeh Shirin Afyouni Akbari

Cortisol is a hormone released in response to stress and is a major glucocorticoid produced by adrenal glands. Here, we report a wearable sensory electronic chip using label-free detection, based on a platinum/graphene aptamer extended gate field effect tr ...

SPRINGERNATURE2021

Sampling and Energy Evaluation Challenges in Ligand Binding Protein Design

Kai Johnsson, Alberto Schena

The steroid hormone 17α-hydroxylprogesterone (17-OHP) is a biomarker for congenital adrenal hyperplasia and hence there is considerable interest in sensor development towards this compound. We used computational protein design to generate protein models wi ...

Cold Spring Harbor Laboratory Press2017

Intestinal steroidogenesis controls PPAR expression in the colon and is impaired during ulcerative colitis

Johan Auwerx

Background and aims Immune tolerance breakdown during UC involves the peroxisome proliferator-activated receptor- (PPAR), a key factor in mucosal homoeostasis and the therapeutic target of 5-aminosalycilates, which expression is impaired during UC. Here we ...

Bmj Publishing Group2015

The effects of extrinsic stress on somatic markers and behavior are dependent on animal housing conditions

Maria del Carmen Sandi Perez, Guillaume Poirier, Michael van der Kooij, Damien Sébastien Huzard

Properties of the environment play an important role in animal wellbeing and may modulate the effects of external threats. Whereas stressors can affect emotion and impair cognition, environmental enrichment may prevent the occurrence of such negative seque ...

Pergamon-Elsevier Science Ltd2015

Evidence of concentration fluctuations in disordered network-forming systems: the case of GeSe4 and SiSe2

Alfredo Pasquarello

In a search for the physical origin of the first sharp diffraction peak (FSDP) in the concentration-concentration partial structure factor S-CC (k) of disordered network-forming materials, we perform first-principles molecular dynamics simulations of liqui ...

2003

The corticosteroid synthesis inhibitors metyrapone and aminoglutethimide impair long-term memory for a passive avoidance task in day-old chicks

Maria del Carmen Sandi Perez

Long-term memory for a passive avoidance task in day-old chicks has proved to depend upon an action of the adrenal steroid corticosterone through specific receptors in a brain region, the intermediate medial hyperstriatum ventrale (IMHV), involved in learn ...

1997

Expression and regulation of the lipoprotein lipase gene in human adrenal cortex

Johan Auwerx

Lipoprotein lipase (LPL), an enzyme which hydrolyzes triglycerides and participates in the catabolism of remnant lipoproteins, plays a crucial role in energy and lipid metabolism. The goal of this study was to analyze the expression and regulation of the L ...

1996

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